Adaptation of the right ventricle (RV) to increased afterload is crucial for survival in pulmonary hypertension (PH), but it is challenging to assess RV function and identify associated molecular mechanisms. The aim of the current study was to analyze the relationship between invasive and noninvasive parameters of RV morphology and function and associated molecular changes. The response of mice...

The structural and functional changes of left right ventricles as well the existence ventricular interaction in patients with arterial hypertenison (AH) were discussed many research papers. Therefore, published data regarding under influence AH are scarce, non-univocal, sometimes contradictory. Furthermore, there is a significant lack clinical trials addressing circadian BP profile on RV struct...

Background Cardiovascular MRI (CMR) assessment of ventricular function in patients with RV pathology requires contouring the right ventricle, which can be time-consuming due to its abnormal shape and extensive trabeculations. A semi-quantitative method to assess RV function in this patient population would be beneficial and would allow for rapid reporting of results. A recent study demonstrated...

Right ventricular (RV) function is the major determinant of mortality in pulmonary arterial hypertension and male sex is a strong predictor of mortality in this disease. The effects of testosterone on RV structure and function in load stress are presently unknown. We tested whether testosterone levels affect RV hypertrophic responses, fibrosis, and function. Male C57BL/6 mice underwent castrati...

Right coronary reactive hyperemia and the maximal coronary vasodilator response to adenosine were examined in conscious, normal dogs and dogs with right ventricular (RV) hypertrophy. RV hypertrophy was induced by chronic (5-7 months) pulmonary artery stenosis. With RV hypertrophy, RV weight to body weight ratio rose by 70% (P < 0.001), right coronary artery blood flow (Doppler ultrasonic techni...

BACKGROUND The right ventricle (RV) receives part of its systolic pumping force from the left ventricle through systolic ventricular interaction. The purpose of this study was to determine the effects of dilated cardiomyopathy on left ventricular to right ventricular (LV-to-RV) systolic interaction. METHODS AND RESULTS Studies were performed in six normal pigs and in six pigs in which dilated...

Despite developments in surgical techniques and other interventions, right ventricular (RV) failure remains an important clinical problem in several congenital heart diseases (CHD). RV function is one of the most important predictors of mortality and morbidity in patients with CHD. RV failure is a progressive disorder that begins with myocardial injury or stress, neurohormonal activation, cytok...

Right and left ventricular volume characteristics were determined from biplane cineangiocardiography in 37 patients with isolated ventricular septal defects. Patients were divided into three categories as determined by the degree of left-to-right shunt: small shunt-less than 35% of pulmonary blood flow (N=9); moderate shunt-35-49% (N=8), and large shunt-greater than 50% (N=20). Right ventricula...

Background Cardiac Magnetic Resonance (CMR) provides superior assessment of right ventricle (RV) function and assessment of multiple physiologic parameters with high interand intraobserver reproducibility thus providing a noninvasive assessment of pulmonary arterial hypertension (PAH) by evaluating RV physiologic parameters. CMR also provides a unique noninvasive assessment of myocardial fibros...

•High-intensity exercise for 45 min induces right- and left-sided cardiac fatigue.•EICF is more pronounced during stress echocardiography.•Exercise under hypoxia does not exaggerate EICF. BackgroundAcute promotes transient exercise-induced fatigue, which affects the right ventricle to a lesser extent left ventricle. Hypoxic exposure an additional increase in ventricular (RV) afterload. Therefor...