Rhomboids are evolutionarily conserved serine proteases that cleave transmembrane proteins within the membrane. The increasing number of known rhomboid functions in prokaryotes and eukaryotes makes them attractive drug targets. Here, we describe structures of the Escherichia coli rhomboid GlpG in complex with β-lactam inhibitors. The inhibitors form a single bond to the catalytic serine and the...

Invasion of host cells by the malaria pathogen Plasmodium relies on parasite transmembrane adhesins that engage host-cell receptors. Adhesins must be released by cleavage before the parasite can enter the cell, but the processing enzymes have remained elusive. Recent work indicates that the Toxoplasma rhomboid intramembrane protease TgROM5 catalyzes this essential cleavage. However, Plasmodium ...

[Purpose] This study examined the activation of the rhomboid muscle according to the angle of the arm. [Subjects and Methods] The current study was conducted on 15 healthy males. The participants performed the pulling exercise in 5 conditions. The surface electromyography system was used to measure the muscle activities of the rhomboid and upper trapezius. [Results] The activity of the upper tr...

The rhomboid fossa of clavicle was studied globally by forensic experts and anthropologists to determine the age and sex. This study was done on samples of human clavicles from North Karnataka of South India to determine the sexual dimorphism which is of anthropological, forensic and clinical importance. In this study mid shaft circumference, morphology of rhomboid fossa of clavicle was analyse...

[Purpose] This study investigated the changes in pressure pain threshold of the upper trapezius, levator scapular, and rhomboid muscles during continuous computer work. [Subjects] Fourteen males and females aged 26-32 years, were recruited. [Methods] A dolorimeter pressure algometer was used to measure the pressure pain threshold of the upper trapezius, levator scapular, and rhomboid muscles, r...

Rhomboid serine proteases are present in many species with Background: sequenced genomes, and are often encoded in each species by more than one predicted gene. Based on protein sequence comparisons, rhomboids can be differentiated into groups secretases, presenilin-like associated rhomboid-like (PARL) proteases, iRhoms, and “inactive” rhomboid proteins. Although these rhomboid groups are disti...

The presence of crystalline inclusions in plasma cell myeloma is a rare phenomenon and cases have been reported with rod, needle, and rectangular shaped crystals. Here, we present a case of IgG lambda restricted plasma cell myeloma with rhomboid shaped intracellular crystalline inclusions and extracellular crystal depositions in the bone marrow. Since rhomboid crystal depositions can be seen in...