نتایج جستجو برای: reverse transcriptase inhibitor

تعداد نتایج: 313286  

2017
Xinli Lu Hongru Zhao Yuqi Zhang Wei Wang Cuiying Zhao Yan Li Lin Ma Ze Cui Suliang Chen

BACKGROUND To understand HIV-1 drug resistance in 11 prefectures of Hebei Province, China, we implemented a cross-sectional HIV-1 molecular epidemiological survey. METHODS Blood samples were collected from 122 newly diagnosed drug-naïve HIV-1-positive individuals and 229 antiretroviral therapy (ART)-failure individuals from 11 prefectures in Hebei Province, China. Patient demographic data wer...

2011
Timothy Juday Kristy Grimm Annette Zoe-Powers James Willig Edward Kim

This study examined factors associated with persistence (time from initiation to discontinuation of treatment) on initial antiretroviral (ARV) therapy in commercially insured HIV patients in the United States, a population not well researched. This retrospective analysis of US health insurance claims data from 1 January 2003 to 30 June 2008 included treatment-naive patients aged 18-65 years wit...

Journal: :Bulletin of mathematical biology 2004
R J Smith L M Wahl

We present an immunological model that considers the dynamics of CD4+ T cells interacting with free virions, reverse transcriptase inhibiting drugs and protease inhibiting drugs. We divide the T cells into multiple classes and use impulsive differential equations to describe the drug activity. As expected, we find that insufficient dosing of either drug corresponds to high viral load and a larg...

Journal: :International Journal of Pharmacy and Pharmaceutical Sciences 2018

Journal: :Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2005
Rangsima Lolekha Sunee Sirivichayakul Umaporn Siangphoe Chitsanu Pancharoen Suchada Kaewchana Wichitra Apateerapong Apicha Mahanontharit Tawee Chotpitayasunondh Kiat Ruxrungtham Praphan Phanuphak Jintanat Ananworanich

The prevalence of nucleoside reverse-transcriptase inhibitor (NRTI) mutations was determined among 95 human immunodeficiency virus-infected Thai children who were treated with dual nucleoside reverse-transcriptase inhibitors. Almost all children had resistance to at least 1 NRTI, and approximately half of the children had resistance to multiple NRTIs. Cross-resistance to stavudine and azidothym...

Journal: :Antimicrobial agents and chemotherapy 2005
Richard J Hazen Robert J Harvey Marty H St Clair Robert G Ferris George A Freeman Jeffrey H Tidwell Lee T Schaller Jill R Cowan Steven A Short Karen R Romines Joseph H Chan Lawrence R Boone

GW678248, a novel nonnucleoside reverse transcriptase inhibitor, has been evaluated for anti-human immunodeficiency virus activity in a variety of in vitro assays against laboratory strains and clinical isolates. When GW678248 was tested in combination with approved drugs in the nucleoside and nucleotide reverse transcriptase inhibitor classes or the protease inhibitor class, the antiviral acti...

Journal: :Antimicrobial agents and chemotherapy 2000
L M Demeter R W Shafer P M Meehan J Holden-Wiltse M A Fischl W W Freimuth M F Para R C Reichman

The development of human immunodeficiency virus type 1 resistance to delavirdine (DLV) was studied in subjects receiving DLV monotherapy. Phenotypic resistance developed in 28 of 30 subjects within 8 weeks. K103N and Y181C, which confer nonnucleoside reverse transcriptase inhibitor (NNRTI) cross-resistance, were the predominant reverse transcriptase mutations. P236L, which confers DLV resistanc...

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