At Chapel Hill, Chapel Hill, North Carolina; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Sistemas Locales de Atención Integral a la Salud, León (SILAIS-León), Leon, Nicaragua; Hospital Escuela Oscar Danilo Rosales Argüello (HEODRA), León, Nicaragua, Leon, Nicaragua; Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill...

W. Gao, H. Zhu, K. Giovanello, K. Smith, D. Shen, J. Gilmore, and W. Lin Department of Biomedical Engineering, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, United States, Department of Biostatistics and BRIC, University of North Carolina-Chapel Hill, Department of Psychology and BRIC, University of North Carolina-Chapel Hill, Department of Radiology, University of Nort...

Many learning tasks involve searching through a discrete space of performance elements, seeking an element whose future utility is expected to be high. As the task of nding the global optimum is often intractable, many practical learning systems use simple forms of hill-climbing to nd a locally optimal element. However, hill-climbing can be complicated by the fact that the utility value of a pe...

When Jim Lyons-Weiler and I discussed what we might do with an Open Access journal on Cancer Informatics, we both felt that it was important to avoid loosing focus on what the end-point of both the research and its dissemination is. In all its forms cancer is inevitably an unpleasant affl iction that harms every aspect of the lives of sufferers and those who love them. Jim and I want this journ...

Awake versus Anesthetized: Layer-Specific Sensory Processing in Visual Cortex and 1 Functional Connectivity between Cortical Areas 2 3 Running Head: Anesthetics Disrupt Sensory Processing 4 5 Kristin K. Sellers, Davis V. Bennett, Axel Hutt , James H. Williams, and Flavio Frohlich 6 7 1 Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill NC 27599 8 2 Neurobiology C...

Substrate inhibition was observed with the heterodimeric (p66/p51) and the homodimeric (p66/p66, p51/p51) forms of human immunodeficiency virus type 1 reverse transcriptase (RNA-dependent DNA polymerase, EC 2.7.7.49). An apparent Ki value of 195 +/- 37 microM was determined for dTTP using the bacterial cloned and expressed heterodimer. Similar values were obtained with the homodimeric and the v...

Rifle shooting produces a sudden counterforce against the body thorough the anterior shoulder, which may produce a traumatic injury in soldiers. Posterior instability of the shoulder can occur in soldiers who practice rifle shooting. To the authors' knowledge, few reports have examined shooting-related injuries in soldiers. This article describes the case of a 27-year-old male soldier who prese...

W. Gao, H. Zhu, K. Giovanello, K. Smith, D. Shen, J. Gilmore, and W. Lin Department of Biomedical Engineering, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, United States, Department of Biostatistics and BRIC, University of North Carolina-Chapel Hill, Department of Psychology and BRIC, University of North Carolina-Chapel Hill, Department of Radiology, University of Nort...

W. Gao, H. Zhu, K. Giovanello, K. Smith, D. Shen, J. Gilmore, and W. Lin Department of Biomedical Engineering, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, United States, Department of Biostatistics and BRIC, University of North Carolina-Chapel Hill, Department of Psychology and BRIC, University of North Carolina-Chapel Hill, Department of Radiology, University of Nort...

Posterior shoulder instability (PSI) accounts for 2% to 10% of all instability, with recurrent posterior subluxation being the most common type. One important risk factors is presence an anterior humeral notch (so-called reverse Hill-Sachs lesion), and lesion in PSI a labral lesion. When conservative treatment fails, surgery recommended provide long-term stability, manage pain, enable return pr...