The revalidation of doctors was introduced in the UK in December 2012, and means that all licensed doctors must demonstrate periodically that they are up-to-date and fit to practise. Regular appraisals, based on the General Medical Council's core guidance for doctors, will be used by responsible officers to evaluate a doctor's practice based on six types of supporting information, including fee...

To obtain new oral drugs in the beyond rule of five space, PROTACs among others, molecular properties should be optimized early drug discovery. Degraders call for design strategies which focus on intramolecular interaction and chameleonicity. In parallel, tailored revalidation permeability assessment prediction methods becomes fundamental this innovative chemical space.

There was a lot of discussion about strengthening professional regulation five or so years ago – but now it really does seem to be happening. So far so good. There seems to be a general confidence that revalidation will be about improving and maintaining individual practitioners’ performance rather than focusing on specific faults. It will hopefully be about enhancing the quality of care and sa...