نتایج جستجو برای: rev1
تعداد نتایج: 346 فیلتر نتایج به سال:
The need for precise and responsive management of N fertilizer in corn production is compelling for both economic and environmental reasons, but the optimum N rate remains an elusive notion. Economically optimal N rates (EONR) in much of North America may range from zero to 225 lb/A (Scharf et al., 2006; Sawyer et al. 2006), and may vary as the growing season progresses (van Es et al., 2007). M...
In metazoans, the mechanism by which DNA is synthesized during homologous recombination repair of double-strand breaks is poorly understood. Specifically, the identities of the polymerase(s) that carry out repair synthesis and how they are recruited to repair sites are unclear. Here, we have investigated the roles of several different polymerases during homologous recombination repair in Drosop...
Translesion DNA synthesis (TLS) is a mode of DNA damage tolerance which plays an important role in genome mutagenesis and chromatin integrity maintenance. Proliferating cell nuclear antigen (PCNA) monoubiquitylation is one of the key factors for TLS pathway choice. So far, it remains unclear how the TLS pathway is elaborately regulated. Here, we report that TLS polymerase REV1 can promote PCNA ...
زمینه و اهداف: بروسلوز از مهم‌ترین بیماری‌های مشترک انسان و دام محسوب می‌گردد. بهترین راه مقابله با بروسلوز انجام واکسیناسیون مناسب میباشد. واکسنهای موجود از قبیل واکسن Rev1 با معایبی چون سقط جنین در حیوانات باردار همراه است لذا تهیه واکسن مناسب برای درمان بروسلوز ضروری می باشد. هدف از انجام این مطالعه، طراحی و ساخت وکتور خودکشی pDS132-ΔkanR به منظور حذف ژن مقاومت به آنتیبیوتیک کانامایسین د...
brucellosis is a well-known infectious disease among domestic animals caused by brucella bacterium. omp25 is an outer membrane protein of brucella which plays an important role in immunogenicity of cells. moreover, brucella lumazine synthase (bls) as another main antigen can be used as an adjuvant when covalently attached to a foreign antigen. in the current study, designing and production of a...
زمینه و اهداف: بروسلوز از مهم ترین بیماری های مشترک انسان و دام محسوب می گردد. بهترین راه مقابله با بروسلوز انجام واکسیناسیون مناسب میباشد. واکسنهای موجود از قبیل واکسن rev1 با معایبی چون سقط جنین در حیوانات باردار همراه است لذا تهیه واکسن مناسب برای درمان بروسلوز ضروری می باشد. هدف از انجام این مطالعه، طراحی و ساخت وکتور خودکشی pds132-δkanr به منظور حذف ژن مقاومت به آنتیبیوتیک کانامایسین د...
Telephone +44 (0)20 7418 8400 Facsimile +44 (0)20 7418 8416 E-mail [email protected] Website www.ema.europa.eu An agency of the European Union © European Medicines Agency, 2014. Reproduction is authorised provided the source is acknowledged. 27 February 2014 EMA/CHMP/CVMP/QWP/BWP/70278/2012-Rev1 Committee for Medicinal Products for Human Use (CHMP) Committee for Medicinal Products for Veterina...
3-Nitrobenzanthrone (3-NBA), a potent mutagen and suspected human carcinogen, is a common environmental pollutant. The genotoxicity of 3-NBA has been associated with its ability to form DNA adducts, including N-(2'-deoxyguanosin-8-yl)-3-aminobenzanthrone (C8-dG-ABA). To investigate the molecular mechanism of C8-dG-ABA mutagenesis in human cells, we have replicated a plasmid containing a single ...
Cisplatin and other DNA-damaging chemotherapeutics are widely used to treat a broad spectrum of malignancies. However, their application is limited by both intrinsic and acquired chemoresistance. Most mutations that result from DNA damage are the consequence of error-prone translesion DNA synthesis, which could be responsible for the acquired resistance against DNA-damaging agents. Recent studi...
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