While the majority of COVID-19 cases are mild and can be managed in outpatient setting, more severe have proven to a clinical challenge. some demonstrate slow indolent decline, others seem deteriorate rapidly with little forewarning. The current literature has connected Retiform Purpura as cutaneous manifestation associated infections, however timing presentation symptoms not been well describe...

A 40-year-old woman presented to the emergency department with a chief complaint of a painful rash. She had noticed lesions on her skin accompanied by burning pain that intensified over a 24-hour period. The patient admitted to smoking “crack” cocaine 4 days prior to presentation. She reported having similar symptoms previously. Her complicated past medical history was significant for hepatitis...

quent inhalational cocaine use was admitted to hospital after presenting to the emergency department with a four-month history of intermittent painful bruises (retiform purpura) involving her arms and legs, with recent ulceration of her nasal tip, ears and cheeks (Figures 1A, 2A and 3A). Previous episodes of the retiform purpura had improved spontaneously following abstinence from inhalational ...

BACKGROUND Cutaneous microvascular occlusion syndromes (MOS) present with noninflammatory retiform purpura with variable outcomes that are dependent on the severity, duration, and specific underlying cause. Transient cases are often associated with few sequelae, while severe forms such as symmetrical peripheral gangrene may be associated with amputation and death. OBSERVATIONS A middle-aged m...