objective(s): mutant forms fms-like tyrosine kinase-3 (flt3), are reported in 25% of childhood acute lymphoid leukemia (all) and 30% of acute myeloid leukemia (aml) patients. in this study, drug response, growth promoting, and protein trafficking of flt3 wild-type was compared with two active mutants (internal tandem duplication (itd)) and d835y. materials and methods:flt3 was expressed on fact...

this paper presents a hybrid method for the optimization of forging process of an aerofoil blade. preform shape and die parting-line angle are optimized in order to minimize the volume of the unfilled die cavity, material waste, forging forces. the overall optimization scheme used in this research work includes a multi-objective approach that is combination of response surface and finite elemen...

common variable immunodeficiency (cvid) is a heterogeneous group of disorders, characterized by hypogammaglobulinemia and increased susceptibility to recurrent infections, autoimmunity and malignancies. we have previously shown that some pediatric patients with cvid can respond to meningococcal polysaccharide vaccine. twelve pediatric cases with cvid were re-evaluated to determine whether bacte...

abstract background: today disasters are a part of many people’s lives. iran has a long history of disaster events and nurses are one of the most significant groups within the iranian disaster relief operations, providing immediate and long-term care for those affected by the disaster. however, the technical competence of iranian nurses and their training for this work has received little atten...

objective: this research was carried out as a greenhouse experiment in the form of a completely randomized factorial design (crd) in three-run sequences. the research aimed at investigating the impacts of nicosulfuron (cruz) and rimsulfuran (titus) residues on the growth of wheat in two soil types which differed in their levels of organic compounds and salinity. methods: treatment of the experi...

our aim was to evaluate the short and long term efficacy of botulinum toxin therapy in iranian patients with achalasia. in a randomized, double blind trial, 20 patients with achalasia, referring to imam khomeini hospital, received either 80 units of botulinum toxin (bt) or placebo (pl) from 1995 to 1998. two weeks later, the response to treatment was assessed on the basis of changes in the symp...

abstract:background : hyperbilirubinemia is one of the most common cause of congenital sensory neuronal hearing loss. these patients are screened by auditory brainstem response (abr) test at bilirubin levels higher than 1% of gestational weight. aim: to determine whether hyperbilirubinemia less than 1% of gestational weight could induce hearing loss and abnormal auditory brainstem response (abr...

background: etomidate and propofol are common anesthetic agents. previous studies say that etomidate can be used in patients with limited hemodynamic reserve and propofol can lead to more hemodynamic instabilities. th is study was performed to explore the cardiovascular response during the induction of anesthesia with etomidate or for comparison, propofol in elective orthopedic surgeries. mater...

problematic dyes extensively used in different industries such as textile, paper, food, plasticsand cosmetics have undesirable environmental effects. white rot fungi demonstrating effective extracellularenzyme system, which is capable of degrading dyes and various xenobiotics. the aim of this study was tooptimize decolorization of reactive blue 19 (rb19) dye using phanerochaetechrysosporium. a ...

background: although a variety of methods have been suggested to reduce stress, anxiety and pain intensity due to spinal needle skin puncture, their adverse effects restrict theirs widespread administration. in this study we evaluated the effects of oral tizanidine on the reduction of pain caused by spinal needle puncture and hemodynamic responses. methods : in this double blind randomized clin...