The present paper describes several models of the central respiratory pattern generator (CRPG) developed employing experimental data and current hypotheses for respiratory rhythmogenesis. Each CRPG model includes a network of respiratory neuron types (e.g., early inspiratory; ramp inspiratory; late inspiratory; decrementing expiratory; postinspiratory; stage II expiratory; stage II constant fir...

PURPOSE Recently, the clinical application of the forced oscillation technique (FOT) has progressed with the spread of commercially available FOT devices, including the impulse oscillation system and MostGraph. We investigated the usefulness of color 3D imaging of respiratory impedance in asthma using MostGraph. METHODS Whole-breath and within-breath respiratory system resistance (Rrs) and re...

Several acid anhydrides are known for their sensitizing and irritative properties. Since both irritation and respiratory allergy can cause changes of lung function, proper testing of allergen-dependent effects on the respiratory tract requires knowledge of the respiratory irritant effects. To study the latter effects, groups of female Brown Norway (BN) and Wistar rats were exposed for 30 min to...

OBJECTIVES Reduction of breathing variability is associated with adverse outcome. During mechanical ventilation, the variability of ventilatory pressure is dependent on the ventilatory mode. During neurally adjusted ventilatory assist (NAVA), the support is proportional to electrical activity of the diaphragm (EAdi), which reflects the respiratory center output. The variability of EAdi is, ther...

48 GPN 2017, Vol 3, No 2 Breathing is a normal vital function which is spontaneous, regular, quiet and effortless and reflects the way that the respiratory system functions. Breathing pattern disorders or dysfunctional breathing, historically known as hyperventilation syndrome, are chronic abnormal respiratory patterns in relation to the efficiency of breathing, often resulting in dyspnoea and ...

BACKGROUND Analysis of breath-to-breath variability of respiratory characteristics provides information on the respiratory control. In infants, the control of end-expiratory lung volume (EELV) is active and complex, and it can be altered by respiratory disease. The pattern of EELV variability may reflect the behavior of this regulatory system. OBJECTIVES We aimed to characterize EELV variabil...

The brainstem respiratory network can operate in multiple functional states engaging different state-dependent neural mechanisms. These mechanisms were studied in the in situ perfused rat brainstem-spinal cord preparation using sequential brainstem transections and administration of riluzole, a pharmacological blocker of persistent sodium current (INaP). Dramatic transformations in the rhythmog...