نتایج جستجو برای: respiratory chain complex

تعداد نتایج: 1238547  

2014
A. A. Khutornenko A. A. Dalina B. V. Chernyak P. M. Chumakov A. G. Evstafieva

A mechanism for the induction of programmed cell death (apoptosis) upon dysfunction of the mitochondrial respiratory chain has been studied. Previously, we had found that inhibition of mitochondrial cytochrome bc1, a component of the electron transport chain complex III, leads to activation of tumor suppressor p53, followed by apoptosis induction. The mitochondrial respiratory chain is coupled ...

2012
Michael Gebert Sandra G. Schrempp Carola S. Mehnert Anna K. Heißwolf Silke Oeljeklaus Raffaele Ieva Maria Bohnert Karina von der Malsburg Sebastian Wiese Thomas Kleinschroth Carola Hunte Helmut E. Meyer Ilka Haferkamp Bernard Guiard Bettina Warscheid Nikolaus Pfanner Martin van der Laan

Many mitochondrial proteins are synthesized with N-terminal presequences in the cytosol. The presequence translocase of the inner mitochondrial membrane (TIM23) translocates preproteins into and across the membrane and associates with the matrix-localized import motor. The TIM23 complex consists of three core components and Tim21, which interacts with the translocase of the outer membrane (TOM)...

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