Pseudomonas aeruginosa (Pa) is the leading cause of chronic lung infection in Cystic Fibrosis (CF) patients. It is well recognized that CF epithelial cells fail to develop an appropriate response to infection, allowing bacterial colonization and a chronic inflammatory response. Since long non-coding RNAs (lncRNAs), are known to play a key role in regulating mammalian innate immune response, we ...

in this research, the effect of different biopolymers such as polyethylene glycol (peg) and polyvinylalcohol (pva) on synthesis and characterization of polymer/cobalt ferrite (cf) nano-composites bymechanical alloying method has been systematically investigated. the structural, morphological andmagnetic properties changes during mechanical milling were investigated by x-ray diffraction (xrd),fo...

It has been proposed that defective submucosal gland function in CF airways is a major determinant of CF airway disease. We tested the hypothesis that submucosal gland function is defective early in CF subjects with minimal clinical disease. Functional assays of gland fluid secretion rate and viscosity were performed on freshly obtained nasal biopsies from 6 CF subjects and 5 non-CF controls (a...

BACKGROUND There are urgent needs for clinically relevant biomarkers to identify children with cystic fibrosis (CF) at risk for more progressive lung disease and to serve as outcome measures for clinical trials. Our objective was to investigate three targeted biomarkers in a population of asymptomatic CF infants. METHODS Urine, blood and lung function data were collected for 2 years from clin...

Background Metabolomics could provide new insights into the pathophysiology of cystic fibrosis (CF) by identifying profiles of endogenous metabolites. Objectives We investigated whether metabolomics of exhaled breath condensate (EBC) could discriminate between patients with unstable CF, stable CF, and healthy subjects, and whether selected metabolites were responsible for between-group differen...

OBJECTIVE Available reports on critically ill adults with cystic fibrosis (CF) suggest improving short-term outcomes. However, there is marked heterogeneity in reported findings, with studies mostly based on single-centered data, limiting generalizability. We sought to examine population-level patterns of demand for critical care resources, and the characteristics, resource utilization, and out...

The tomato resistance genes Cf-4 and Cf-9 confer specific, hypersensitive response-associated recognition of Cladosporium carrying the avirulence genes Avr4 and Avr9, respectively. Cf-4 and Cf-9 encode type I transmembrane proteins with extracellular leucine-rich repeats (LRRs). Compared with Cf-9, Cf-4 lacks two LRRs and differs in 78 amino acid residues. To investigate the relevance of these ...

A novel reactive P-N intumescent flame retardant tetroxo (3-triethylphosphine-5-chlorine-1-triazine) neopentane (TTCTN) was prepared, and its structure determined by Fourier transform infrared (FTIR) nuclear magnetic resonance (NMR). The retardance physiological comfort properties of TTCTN-treated cotton fabrics (TTCTN-CF) researched. CF treated with 20 wt% TTCTN (TTCTN(20)-CF) showed the limit...