The Food and Drug Administration (FDA) recently released a final rule to ban triclosan and 18 other antimicrobial chemicals from soaps. We applaud this rule specifically because of the associated risks that triclosan poses to the spread of antibiotic resistance throughout the environment. This persistent chemical constantly stresses bacteria to adapt, and behavior that promotes antibiotic resis...

TolC is the outer-membrane component of several multidrug resistance (MDR) efflux pumps and plays an important role in the survival and virulence of many gram-negative bacterial animal pathogens. We have identified and characterized the outer-membrane protein-encoding gene tolC in the bacterial plant pathogen Erwinia chrysanthemi EC16. The gene was found to encode a 51-kDa protein with 70% iden...

Wholesome nutrition is the key to maintaining a healthy immune system and resistance to disease. Commercial foods ingested by animals on a regular basis may not be balanced in terms of major nutrients, minerals and vitamins, and some continue to add chemicals to the final product to enhance its stability and shelf-life. Nutritional deficiencies or imbalances as well as exposures to various chem...

Introduction The competition for crops between human and insects is as old as agriculture. The use of chemical substances to control pests was started in the mid-1800s. In past, certain inorganic and organic compounds, including organochlorides, organophosphates, carbamatespyrethroids and formamides were used as insecticides. Because of the special properties of these chemicals, such as long re...

BACKGROUND Polyfluoroalkyl chemicals (PFCs) are used commonly in commercial applications and are detected in humans and the environment worldwide. Concern has been raised that they may disrupt lipid and weight regulation. OBJECTIVES We investigated the relationship between PFC serum concentrations and lipid and weight outcomes in a large publicly available data set. METHODS We analyzed data...

A NUMBER of recent studies have shown that the growth of certain rodent tumouirs may be inhibited by the oral administration of the H-2 antagonist cimetidine (Gifford et al., 1981; Osband et al., 1981). Furthermore, it has been proposed that the antitumour effects of this compound are due to its ability to inhibit histamineinduced T-suppressor-cell activation (Osband et al., 1980a, 1981; Ogden ...