The coevolution of female mate preferences and exaggerated male traits is a fundamental prediction of many sexual selection models, but has largely defied testing due to the challenges of quantifying the sensory and cognitive bases of female preferences. We overcome this difficulty by focusing on postcopulatory sexual selection, where readily quantifiable female reproductive tract structures ar...

In female rats, in uteroexposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) during critical periods of organogenesis causes a permanent thread of tissue, consisting of a core of mesenchyme surrounded by keratinized epithelia, across the vaginal opening. The objective of the current study was to determine the earliest time after exposure to TCDD during fetal development that morphological cha...

P151 Protein Expression of Cortisol Metabolising Enzymes in the Boar Reproductive Tract V Sharp, AE Michael and LM Thurston Royal Veterinary College, University College London, London, UK The stress hormone cortisol is implicated in a wide range of reproductive processes including semen quality. Cortisol is interconverted with cortisone by isoforms of the enzyme 11beta hydroxysteroid dehydrogen...

Estrogen is synthesized in the male reproductive system and is found in high concentrations in rete testis and seminal fluids. This luminal estrogen targets estrogen receptors (ER) along the male reproductive tract, and in particular the efferent ductules, where ERalpha is abundant. However, both ERalpha and ERbeta are found in various regions of the male reproductive tract. The transgenic ER k...

Successful mammalian reproduction requires that sperm migrate through a long and convoluted female reproductive tract before reaching oocytes. For many years, fertility studies have focused on biochemical and physiological requirements of sperm. Here we show that the biophysical environment of the female reproductive tract critically guides sperm migration, while at the same time preventing the...

Abstract Background The microbiome is still a new area of research in human health and disease, especially reproductive health. present article aims to aid the perception on tract that may enable better management its dysbiosis causing dysfunctions. Main body In recent years, identification microbiota every part has been eased by next-generation sequencing-based tools. It demonstrated resident ...

BACKGROUND The 12 kD FK506 binding protein FKBP12 is a cytosolic receptor for the immunosuppressant drugs FK506 and rapamycin. In addition to its critical role in drug-induced T-cell immunosuppression, FKBP12 associates physiologically with ryanodine and inositol 1,4,5-trisphosphate (IP3) receptors, regulating their ability to flux calcium. We investigated a role for FKBP12 in male reproductive...