Background: There is an important evidence that prolonged exposure to several endocrine disrupting chemicals (EDCs). These are persistent materials with unique environmental properties such as intake of contaminated food, water and air, irrespective of proximity to industries, which are suspected to have endocrine disrupting activities. Perflurooctanoic acid (PFOA) and diethylstilbestrol (EDCs)...

Maternal obesity is a risk factor for the development of metabolic syndrome and childhood obesity, and early overnutrition seems to induce the development of pathologies in adulthood, including insulin resistance, cardiovascular diseases, type 2 diabetes mellitus, and a higher BMI. In addition, it is known that obesity can negatively affect fertility and reproductive function in men. The object...

Weightlessness is known to induce many pathophysiological changes in various organs and systems in simulated weightlessness animal models. However, there is limited data on the effects of weightlessness on the female reproductive system. In the present study, we used the Morey-Holton hind limb suspension model to simulate weightlessness in female rats. We have shown that this weightlessness ind...

Some pesticides may interfere with the female hormonal function, which may lead to negative effects on the reproductive system through disruption of the hormonal balance necessary for proper functioning. Previous studies primarily focused on interference with the estrogen and/or androgen receptor, but the hormonal function may be disrupted in many more ways through pesticide exposure. The aim o...

Reproductive health problem is more common nowadays and various causes like nutritional defect, socio-economic problems, life style changes are reason for that, among those reason, one important factor is environmental factor. In this study, the pesticide, Lindane is used to induce reproductive toxicity and the levels of male reproductive hormone, antioxidant and histopathology of rat testis wa...

background: chemicals are among risk factors that can affect women's reproductive system. this study is aimed to investigate the association of occupational exposure to a mixture of organic solvents with menstruation disturbances and hormonal changes among female workers. methods : female workers of a pharmaceutical company were divided into three groups of non-exposed, low-exposed and highly-e...

Previous reports on the inverse association between ‘mate’ intake (infusion of Ilex Paraguariensis herb) and breast cancer (BC) risk led us to consider two main roles for the infusion: as a substantial antioxidant contributor and as a hormone regulator, particularly through anti-aromatase capacities. Since menstrual-reproductive risk factors for BC reflect women’s estrogenic exposure during the...

The objective of this study was to examine the impact of polymorphisms in the acyl-CoA:diacylglycerol acyltransferase (DGAT1), leptin and growth hormone receptor genes on body energy (body condition score, total body energy content and cumulative effective energy balance) and blood metabolic traits (levels of beta-hydroxybutyrate, glucose and non-esterified fatty acids), measured once before th...

This study investigated the toxicity of sodium fluoride on male reproductive hormones and ameliorative effects extract Phyllantus amarus adult albino rats. The consisted six equal groups five rats that were administered with over a period two weeks. result indicates possible hormone lipid profile probable capacity to ameliorate this toxicity.

Reproductive function in mammals is energetically costly and therefore tightly regulated by nutritional status. To enable this integration of metabolic and reproductive function, information regarding peripheral nutritional status must be relayed centrally to the gonadotropin-releasing hormone (GNRH) neurons that drive reproductive function. The metabolically relevant hormones leptin, insulin a...