We present a hypothesis emphasizing the role of mitochondrial dysfunction in reproductive senescence and suggesting the use of mitochondrial nutrients as an adjuvant treatment in older patients with infertility.

Recent diagnostic and therapeutic advances in oncology have led to greater survival rates in children and reproductive aged adults with malignancies. However, while cancer therapies improve long-term survival, such treatments can lead to a variety of reproductive problems including abnormal pubertal development, infertility, premature gonadal failure, and sexual dysfunction [1, 2]. As more chil...

Reproductive dysfunction and malignancies related to the male gender represent a serious health concern, whose incidence has significantly risen over the past years. Prior to treatment, testicular or prostate cancer patients often display poor semen characteristics similar to subfertile or infertile patients. This fact is underscored by cases where the malignancy is often diagnosed in males who...

The highly conserved nature of the thyroid gland and the thyroid system among mammalian species suggests it is critical to species survival. Studies show the thyroid system plays a critical role in the development of several organ systems, including the reproductive tract. Despite its highly conserved nature, the thyroid system can have widely different effects on reproduction and reproductive ...

OBJECTIVE To evaluate whether time to pregnancy (TTP) is associated with neurological condition of 2-year-old children born to subfertile parents. DESIGN Data collected in a prospective, assessor-blinded follow-up study were used for cross-sectional analyses. PATIENTS Participants were the singletons of the Groningen assisted reproductive technique cohort study: all children were born to su...

Post-partum uterine disorders and reproductive tract infections cause ovarian dysfunction and infertility. Histone deacetylases (HDACs) prevent the relaxation of chromatin, and positively or negatively regulate transcription. Hence, HDACs play a pivotal role in altering the gene expression that impact different signalling pathways underling ovarian dysfunction. Thus, HDAC inhibitors (HDACi) may...

Endosulfan as a new member of persistent organic pollutants has been shown to induce reproductive dysfunction in various animal models. However, the action mechanism of endosulfan-produced reproductive toxicity remains largely unknown. This study was focused on investigating the reproductive toxicity induced by α-endosulfan and clarifying the role of mitochondria and genotoxic response genes in...

Central to the study of speciation is the identification of the isolating mechanisms that reduce gene flow. Of special interest are those isolating mechanisms that are the earliest to arise. Sperm fate and function play a major role in two distinct types of reproductive isolation in the genus Drosophila. First, postcopulatory-prezygotic (PCPZ) incompatibilities between the male ejaculate and a ...

Background Reproductive dysfunction and endocrine disorders are common among men with complex partial seizures of temporal lobe origin. Diminished sexual desire and responsiveness along with decreased libido and less orgasm are frequently described in men with temporal lobe epilepsy (TLE). It appears that the reduced fertility in epileptic men is accompanied by erectile dysfunction and abnormal...

BACKGROUND Hypertension is a major public health epidemic that is highly associated with sexual dysfunction in both men and women. Despite its high prevalence, clinical and animal literature on the underlying mechanisms of sexual dysfunction in hypertensive women is remarkably limited. METHODS Using a well-established rodent model of renovascular hypertension-the 2-kidney, 1-clip (2K1C) Goldb...