The migration of cells and growth cones is a process that is guided by extracellular cues and requires the controlled remodeling of the extracellular matrix along the migratory path. The ADAM proteins are important regulators of cellular adhesion and recognition because they can combine regulated proteolysis with modulation of cell adhesion. We report that the C. elegans gene unc-71 encodes a u...

The Quail Neuroretina clone 71 gene (QNR-71) is expressed during the differentiation of retinal pigmented epithelia and the epidermis. It encodes a type I transmembrane glycoprotein that shares significant sequence homologies with several melanosomal proteins. We have studied its intracellular traffic in both pigmented and non-pigmented cells. We report that a di-leucine-based sorting signal (E...

purpose : to report a patient with retained broken probe tip in the false passage site after nasolacrimal duct (nld) probing case report : a 18-month-baby with epiphora and a nontender mass in the site of lacrimal sac was visited in clinic. she had a history of probing six months ago by another ophthalmologist. the probing was repeated successfully but the mass size didn’t change. the mass was ...