The standard linear-quadratic (LQ) survival model for external beam radiotherapy is reviewed with particular emphasis on studying how different schedules of radiation treatment planning may be affected by different tumour repopulation kinetics. The LQ model is further examined in the context of tumour control probability (TCP) models. The application of the Zaider and Minerbo non-Poissonian TCP...

Alemtuzumab exerts its clinical efficacy by its specific pattern of depletion and repopulation of different immune cell subsets. Recently, single cases of multiple sclerosis patients who developed severe exacerbation after the first alemtuzumab application, accompanied by re-appearance of peripheral B cells, were reported. Here we present a case with underlying B cell-driven multiple sclerosis ...

By JOHN A. MANNICK, HARRY L. LOCHTE, JR., E. DONNALL THOMAS AND JOSEPH W. FEBREBEE R ECENT STUDIES have indicated the usefulness of stored marrow in the repopulation of marrow spaces after lethal irradiation.’4 The viability of marrow stored for this purpose is definitively demonstrated by survival of the irradiated recipient. A satisfactory in vitro test of viability, however, is essential for...