Transfusion-related acute lung injury (TRALI), the leading cause of transfusion-related death, is underreported by clinicians. For TRALI research, a clinician-independent, computerized system has been developed to detect patients with acute respiratory distress posttransfusion. A computer system generates an alert when a blood gas result indicated a PaO2:FiO2 ratio below 300, within twelve hour...

Rigorous control procedures adopted presently by blood banks have reduced transfusionassociated risks, such as transmission of infectious diseases. Nevertheless, other complications related with blood-transfusions remain, such as transfusion-related acute lung injury (TRALI) and other immune disorders. In critically ill patients, transfusion has been associated with increase in morbidity and mo...

Transfusion-related acute lung injury (TRALI) remains a significant cause of transfusion-related mortality with red cell transfusion. We hypothesize that prestorage filtration may reduce proinflammatory activity in the red blood cell (RBC) supernatant and prevent TRALI. Filters were manufactured for both small volumes and RBC units. Plasma containing antibodies to human lymphocyte antigen (HLA)...

“blood” volume requires overtransfusion with whole blood, plasma, and other iso-oncotic products. Although “congestion” on this basis alone was once spoken of, it is a now a rare event. Until the pulmonary edema associated with the transfusion of packed RBCs and plasma derivatives (TRALI) is reported together with accurate infused volumes of crystalloid and colloid, and concurrent changes in pa...

Transfusion-related acute lung injury (TRALI) is a life-threatening complication of hemotherapy. We report a series of 90 TRALI reactions in 81 patients secondary to transfusion with whole blood platelets (72 reactions), apheresis platelets (2), packed red cells (15), and plasma (1). The overall prevalence was 1 in 1120 cellular components. To examine the epidemiology of TRALI, we completed a n...

BACKGROUND The etiology of transfusion-related acute lung injury (TRALI) is often referred to as a "two-hit model," the first hit being patient predisposition and the second being a transfusion. This model lumps all patient-related risk factors together and thereby may hamper identification of individual, potentially preventable or modifiable risk factors. STUDY DESIGN AND METHODS Like any di...

• TRALI may be induced by antibodies to HLA or HNA antigens or lipids, which accumulate during storage. • Prestorage experimental filtration of RBCs removes HLA and HNA antibodies, decreases lipid priming activity, and mitigates TRALI in an animal model. Transfusion-related acute lung injury (TRALI) remains a significant cause of transfusionrelated mortality with red cell transfusion. We hypoth...