نتایج جستجو برای: regulatory t cells tregs
تعداد نتایج: 2028005 فیلتر نتایج به سال:
CD4+ CD25+ Foxp3+ regulatory T cells (Tregs) are highly sensitive to IL-2, one of the many cytokines produced during immune responses, for their development, survival and functions. Although effects IL-2 administration on Tregs in vivo well characterized, elicited by an response have not been elucidated. Hence, this study, Treg behaviour IL-2–producing responses was explored using vitro murine ...
Chimeric antigen receptors (CARs) are a breakthrough in genetic engineering that have revolutionized the field of adoptive cellular therapy (ACT). Cells expressing these rerouted to predefined target by inclusion an antigen-specific binding region within synthetic CAR construct. The advantage cells with programmed specificity has been demonstrated clinically oncology, and it is clear such great...
It is well established that CD4(+)CD25(+) regulatory T cells (Tregs) inhibit autoimmune pathology. However, precisely how the behavior of disease-inducing T cells is altered by Tregs remains unclear. In this study we use a TCR transgenic model of diabetes to pinpoint how pathogenic CD4 T cells are modified by Tregs in vivo. We show that although Tregs only modestly inhibit CD4 cell expansion, t...
Regulatory T cells, or Tregs, have been shown to play a major role in reducing Th2 cell proliferation, potentially reducing (often significantly) airway-associated inflammation seen in airway diseases, such as asthma. These cells are characterized as a sub-population of T cells that maintain peripheral tolerance through a variety of biological mechanisms. Although Tregs make up only 5-10% of pe...
Abstract Regulatory T cells (Tregs) harness a central role in peripheral immune tolerance. Since its discovery, there have been numerous efforts to dissect the of Tregs context disease condition. Recently, Treg fields are moving from academia industry since many evidences accumulated for potential treatment inflammatory by administering genetically engineered Tregs. However, pre-clinical or cli...
In this article, we review the role of T regulatory cells (Tregs) in the development and prevention of type 1 diabetes. We first examine the definition of human Tregs, the generation of Tregs in the thymus and the periphery, their mode of action and their important role in the regulation of the immune response. We then examine the defects in Tregs observed thus far in type 1 diabetes and their ...
Juvenile dermatomyositis (JDM) is an immune-mediated inflammatory disease affecting the microvasculature of skin and muscle. CD4+ CD25+ FOXP3+ regulatory T cells (Tregs) are key regulators of immune homeostasis. A role for Tregs in JDM pathogenesis has not yet been established. Here, we explored Treg presence and function in peripheral blood and muscle of JDM patients. We analyzed number, pheno...
Regulatory T cells (Tregs) and plasmacytoid dendritic cells (pDCs) that infiltrate primary breast tumors impair patient survival. The ICOS-mediated interaction between tumor-infiltrating CD4+ T cells and pDCs leads to the amplification of Tregs and interleukin-10 secretion. Importantly, ICOS+ cell infiltration correlates with adverse patient prognosis, identifying ICOS as a new target for cance...
Regulatory T cells (Tregs) are indispensable for the maintenance of immunological self-tolerance and homeostasis. Heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) is required optimal Treg induction. Here, we reveal that human-induced Tregs (iTregs) lacking hnRNPA1 show reduced expression transcription factor FOXP3, increased ubiquitination level impaired suppressive abilities. Human naïve C...
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