Ion channels are critical regulators of neuronal excitability and synaptic function in the brain. Recent evidence suggests that ion channels expressed by neurons within the brain are responsible for regulating energy and glucose homeostasis. In addition, the central effects of neurotransmitters and hormones are at least in part achieved by modifications of ion channel activity. This review focu...

The Protein Leverage Hypothesis (PLH) predicts that humans prioritize protein when regulating food intake. We tested a central prediction of PLH: protein intake will remain more constant than fat or carbohydrate in the face of dietary changes in a free-living population. Data come from a large sample of adult Filipino women participating in the Cebu Longitudinal Health and Nutrition Survey (CLH...

This article reviews factors that contribute to excessive weight gain in children and outlines current knowledge regarding approaches for treating pediatric obesity. Most of the known genetic causes of obesity primarily increase energy intake. Genes regulating the leptin signaling pathway are particularly important for human energy homeostasis. Obesity is a chronic disorder that requires long-t...

The effect of supplementation with 1% conjugated linoleic acid and 1% n-3 long chain polyunsaturated fatty acids (CLA/n-3) was assessed in rats. Food intake increased with no difference in body weights. White adipose tissue weights were reduced whereas brown adipose tissue and uncoupling protein-1 expression were increased. Plasma adiponectin, triglyceride and cholesterol levels were reduced wh...

BACKGROUND Obesity associated with type 2 diabetes, and hypertension increased mortality and morbidity. Glutamate decarboxylase 2 (GAD2) gene is associated with obesity and it regulate food intake and insulin level. We investigated the association of GAD-2gene -243A>G (rs2236418) and +61450C>A (rs992990) polymorphisms with obesity and related phenotypes. METHODS Insulin, glucose and lipid lev...

Objective(s):Consumption of high-fat foods is one of the major causes of obesity. Physical exercise is a strategy used to counteract obesity. The aim of this study was to investigate the effect of eight weeks endurance training and high-fat diet (HFD) on appetite-regulating hormones in rat plasma. Materials and Methods:Twenty eight male Wistar rats were randomly divided into four groups: Contro...

In this study, the effects of different methods feeding turkeys on neuropeptide nesfatin-1 and hormone irisin were evaluated. A total 90 distributed to three treatment groups, namely T1: conventional system, T2: 50% feed pasture, T3: pasture. There 30 birds in each group with random replications. The fed for 18 weeks. At end blood was collected from 10 group. Plasma levels measured an enzyme-li...