5-acyl-6-methyl-4-substituted-2-thioxo-1,2,3,4-tetrahydropyrimidines (1) were synthesized by cyclocondensation reaction between appropriate aldehyde, acetoacetate and thiourea in presence of aluminium chloride and hydrochloric acid which upon treatment with dimethylformamide and phosphorous oxychloride furnish the title compounds (2a-j). The structures of all title compounds have been confirmed...

To detect genetic association with common and complex diseases, two powerful yet quite different multimarker association tests have been proposed, genomic distance-based regression (GDBR) (Wessel and Schork [2006] Am J Hum Genet 79:821–833) and kernel machine regression (KMR) (Kwee et al. [2008] Am J Hum Genet 82:386–397; Wu et al. [2010] Am J Hum Genet 86:929–942). GDBR is based on relating a ...

This study examines the correlation and prediction between sunspots solar flux, two closely related factors associated with activity, covering period from 2005 to 2022. The utilizes a combination of linear regression analysis ARIMA method analyze relationship these forecast their values. results reveal significant positive flux. Additionally, suggests that SARIMA model can effectively values bo...

Nell’analisi della dipendenza di una o più variabili quantitative da un set di predittori il metodo dei Minimi Quadrati gioca un ruolo fondamentale. La Teoria delle Probabilità e l’Inferenza classica consentono di valutare l’incertezza delle stime ottenute, mediante la costruzione di opportuni intervalli di confidenza, imponendo al modello ipotesi restrittive spesso difficili da soddisfare. Ino...

Binary Logistic Regression (BLR) has been developed as non-linear models to establish quantitative structure- activity relationships (QSAR) between structural descriptors and biochemical activity of carbonic anhydrase inhibitors. Using a training set consisted of 21 compounds with known ki values, the model was trained and tested to solve two-class problems as active or inactive on the basi...

based on current expectations, when the free float is more, more deals done and consequently the share price volatility will also increase. shareholders expect more profits from stocks which have more free floats. this paper examines the kind of relationship between free float and liquidity, risks and returns and the degree of influence of these variables in the percentage of free float. we con...