نتایج جستجو برای: refractory nhl lymphoma
تعداد نتایج: 155852 فیلتر نتایج به سال:
background: non-hodgkin lymphoma (nhl) includes a wide range of diseases with different clinical and biological features. nhl is usually presented as localized or generalized lymphadenopathy. it has been suggested that the hla class i and ii are associated with susceptibility to nhl. different ethnic groups have been found to have different hla class i and ii alleles which affect nhl. objective...
Approximately 1.5 million people worldwide are living with various forms of lymphoma, and it is estimated that 300 000 people will die each year. In terms of incidence and mortality, non-Hodgkin’s lymphoma (NHL) is the second fastest growing cancer in the USA and the third fastest growing in the rest of the world. Each year ∼60 000 people in the USA will be diagnosed with NHL. More than half of...
BackgroundNonHodgkin lymphoma (NHL) is one of the most frequent malignancies in children and adolescents. It represents lymphoid malignancies with diverse clinicopathological and biological features. There are very few studies on the frequency and distribution of NHL in this age group classified according to the WHO classification of 2008. A total of 246 cases with lymphoma were diagnosed in pe...
PURPOSE To assess the efficacy and toxicity of liposomal daunorubicin administered as a two-hour intravenous infusion to patients with relapsed or refractory non-Hodgkin's lymphoma (NHL). PATIENTS AND METHODS Eligible patients had relapsed or refractory NHL with measurable or evaluable disease, and low grade, select intermediate grade, or mantle cell pathologic types. Prior exposure to an ant...
AIMS To determine the spectrum of renal lesions in patients with kidney involvement in non-Hodgkin's lymphoma (NHL) by renal biopsy. METHODS The clinical features and histological findings at the time of the renal biopsy were assessed for each patient. RESULTS We identified 20 patients with NHL and renal involvement, and the diagnosis of NHL was established following the kidney biopsy in 18...
The gastrointestinal tract is the most common location for primary extranodal non-Hodgkin lymphoma (NHL) with cases less commonly found in the intestine. The majority of primary intestinal B-cell lymphomas are exophytic, whereas enteropathy-associated T-cell lymphomas present predominantly as thickened plaques, ulcers or strictures. Crohn's disease (CD) is a chronic inflammatory disease of the ...
PURPOSE The pharmacology, pharmacokinetics, clinical efficacy, safety and tolerability, dosing and administration, and place in therapy of idelalisib, a targeted therapy for certain types of non-Hodgkin's lymphoma (NHL), are reviewed. SUMMARY Historically, conventional cancer chemotherapy agents were recommended for the management of progressive lymphomas requiring systemic treatment; in rece...
Newave Pharmaceutical is developing an investigational compound LP-118, a next generation selective B-cell lymphoma 2 (BCL-2) inhibitor with tuned extra-large (BCL-XL) activity to improve antitumor efficacy and reduce risk for thrombocytopenia. Clinical development of LP-118 includes targeting relapsed or refractory hematological malignancies. BCL-2 BCL-XL are important anti-apoptotic proteins ...
Non-Hodgkin's lymphomas (NHL) are a heterogeneous group of lymphoproliferative disorders originating in B lymphocytes, T lymphocytes, or natural killer cells. Mantle cell lymphoma (MCL) accounts for approximately 6% of all newly diagnosed NHL cases. Radiation therapy with or without systemic therapy is a reasonable approach for the few patients who present with early-stage disease. Rituximab-ba...
Patients with recurring T-cell non-Hodgkin lymphoma (T-NHL) are incurable and candidate for investigational agents. Here, we report on five patients with T-NHL refractory to multiple chemotherapy lines, including in all cases alkylators and gemcitabine, who received the third-generation chloroethylnitrosourea fotemustine at a dose of 120 mg/m(2) every 21 d, up to eight courses. Median actual d...
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