Brazilian physician and researcher Henrique da Rocha Lima was born in 1879 in the city of Rio de Janeiro, where he studied medicine and obtained the degree of M.D. in 1901. He specialized in Clinical Medicine in Germany and was the ambassador in European countries of the scientific medicine that emerged from the Oswaldo Cruz Institute in the early twentieth century. Rocha Lima has discovered th...

This review article is a tribute to the genius of Professor Erich Muhe, a man ahead of his times. We trace the development of laparoscopic cholecystectomy and detail the tribulations faced by Muhe. On the occasion of the twentieth anniversary of the first laparoscopic cholecystectomy, we take another look at some of the controversies surrounding this gold standard in the management of gallbladd...

? mil a Zelda, mercurial child of the hectic '20s, captured the love of novelist, F. Scott Fitzgerald. In a frenzied effort to match his genius she threw herself into painting, writing and ballet before tragically ending her life in a mental hospital.

Ibn Sina, the most eminent Muslim physician, illuminative philosopher, great thinker and a versatile genius is regarded as the "Father of Early Modern Medicine" and as the "Father of Clinical Pharmacology". The "Kitab al-Qanun fi-al-Tibb", commonly known as the "Canon Medicinae" is the most important of his medical works and, at the same time, the most carefully preserved treasury both in origi...

John Forbes Nash, Jr. was a child prodigy. While other boys his age were playing childhood games in their hometown of Bluefield, West Virginia, John was reading E.T. Bell’s Men of Mathematics. Learning more at home than he did at school, the young lad (who was encouraged by his educated parents) was able to solve some of math’s most difficult problems. Accepting a full-ride fellowship to Prince...

When Jacob Bronowski died in 1974, we lost one of the great minds of the twentieth century. His was a mind which could originate and develop complex theories in mathematics, biology, economics, and philosophy; yet his widespread appeal was certainly due in some part to his ability to think on the spot and communicate his ideas in common terms. This posthumous volume, which transcribes a series ...

Label-free detection of the interaction between hexahistidine-tagged human κ-opioid receptor membrane protein and anti-His antibody is demonstrated in liquid by an optical microelectromechanical system utilizing electromagnetically actuated microresonators. Shift in resonance frequency due to accretion of mass on the sensitive surface of microresonators is monitored via an integrated optical re...

We evaluate the ability of hexahistidine (His6) tags on peptide and protein substrates to recruit deoxyribozymes for modifying those substrates. For two different deoxyribozymes, one that creates tyrosine-RNA nucleopeptides and another that phosphorylates tyrosine side chains, we find substantial improvements in yield, kobs, and Km for peptide substrates due to recruiting by His6/Cu(2+). Howeve...