Production of drug nanoparticles is an effective strategy to enhance solubility and oral absorption of water-insoluble drugs. The handling of drug nanoparticles has been an important issue in drug formulation because nanoparticles easily aggregate each other and redispersion of these particles is very difficult. In the present study, we developed a unique two-solution mixing type spray nozzle t...

This work investigated the redispersion and setting behavior of highly loaded (~ 18 wt.% solids in water) pastes cellulose nanofibrils (CNFs) with carboxymethyl (CMC). A single-screw extruder was used to continuously process CNF + CMC into cord. The adsorption onto CNFs assessed through zeta potential titration which revealed a surface charge change ~ 61% from ? 36.8 mV 0.094 mmol/g COOH for pu...

Aims: The purpose of this study was to evaluate the quality an extemporaneous formulation losartan potassium oral suspensions from crushed tablets ensure that compounded suspension maintained its attributes during storage period.
 Methodology: Losartan were extemporaneously in same way they are prepared for patients at a hospital pharmacy. kept refrigerator 4°C and evaluated immediately af...

Alumina-supported Pt is one of the major industrial catalysts for light alkane dehydrogenation. This catalyst loses activity during reaction, with coke formation often considered as the reason for deactivation. As we show in this study, the amount and nature of carbon deposits do not directly correlate with the loss of activity. Rather, it is the transformation of subnanometer Pt species into l...

We report on a stabilization effect on the structure and activity of Ag/Al2O3 for the selective catalytic reduction (SCR) of NOxwith CH4 imparted by the presence of SO2 in the exhaust gasmixture. The reaction is carried out at temperature above 600 8C to keep the surface partially free of sulfates. In SO2-free gases, catalyst deactivation is fast and measurable at these temperatures. Time-resol...

The aim of the present study was to make a fenofibrate (FNB) nanocrystal (NC) by wet media milling, characterizations and formulates into oral strip-films (OSFs). Mechanical properties, redispersion study, and solid-state characterizations results suggested that reduction of drug crystal size at nanoscale and incorporation into OSFs does not affect the solid-state properties of the drug. In vit...

The radial array of cytoplasmic microtubules (MTs) provides routes for intracellular transport and defines spatial organization of cytoplasm through interaction with molecular motors bound to membrane organelles (Kellogg et al., 1994; Hirokawa, 1998). The array is believed to be organized by the centrosome, which is capable of nucleating MTs. Our recent studies of pigment transport (Rodionov an...

The phase behavior of a series of carbohydrate-based gemini surfactants with varying spacer lengths was studied using static and dynamic light scattering between pH 2 and 12. Cryo-electron microscopy pictures provide evidence for the different morphologies present in solution. The spacer length of the gemini surfactants was varied from two to 12 methylene units. At near neutral pH, spherical ve...