Red Blood Cell (RBC) transfusion is a common medical procedure, which most often involves stored RBC units. During storage, RBC quality degrades due to various factors (“storage lesion”). This decreases cell viability in-vivo and thus often compromises transfusion efficacy. The degradation of any given unit of RBC solution varies according to several factors besides time (e.g., variability amon...

Leg ulcer is a disabling complication in patients with sickle cell anemia (SCA) but the exact pathophysiological mechanisms are unknown. The aim of this study was to identify the hematological and hemorheological alterations associated with recurrent leg ulcers. Sixty-two SCA patients who never experienced leg ulcers (ULC-) and 13 SCA patients with a positive history of recurrent leg ulcers (UL...

background: asphyxia is a common cause of perinatal mortality in 5-10% of all births worldwide. the present parameters for determining perinatal asphyxia, e.g. preeclampsia, cannot be considered as markers per se, and require auxiliary markers, e.g. increased number of nucleated red blood (nrbc) cells, for early diagnosis of perinatal asphyxia. objective: in this study, we evaluated the mean nr...

OBJECTIVE This study was conducted to investigate the effects of low-level laser (LLL) doses on human red blood cell volume. The effects of exposure to a diode pump solid state (DPSS) (λ = 405 nm) laser were observed. BACKGROUND DATA The response of human blood to LLL irradiation gives important information about the mechanism of interaction of laser light with living organisms. Materials and...

In a number of clinical circumstances it would be desirable to artificially conceal cellular antigenic determinants to permit survival of heterologous donor cells. A case in point is the problem encountered in transfusions of patients with rare blood types or chronically transfused patients who become allosensitized to minor blood group determinants. We have tested the possibility that chemical...

background and aims: iron deficiency anemia (ida) and beta thalassemia minor (btm) are the most common hypochromic microcytic anemias, and it is regarded important to differentiate between them. several formulae can be taken into consideration based on red blood cell (rbc) parameters in order to distinguish between these two disorders. hence, the present study intended to evaluate the sensitivi...

A 68-year-old male, known case of abdominal aortic dissection and recent aortic stent insertion, presented with gross hematuria. The urologists suspected aoro-ureteric fistula and performed open surgery (ureterolysis). Tc-99m labeled red blood cell (99mTc-RBC) scintigraphy was ordered to confirm the diagnosis and localize the possible aorto-ureteric fisula, Considering sustained gros...

Following a brief introduction to properties of the red blood cell (RBC), this review will provide information pertaining to the role of the RBC as both a deliverer of nitric oxide (NO), and a stimulator of NO release via RBCgenerated ATP. In addition, an evaluation of the potential downstream effects of RBC-derived ATP, via its ability to stimulate NO in other cell types, will be provided. Col...

Cancer Chemo-Immunotherapy In article number 2103497, Yubin Huang, Dongfang Zhou, and co-workers demonstrate an engineered endogenous tumor-associated macrophages (TAMs)-targeting biomimetic nano-red-blood-cell (RBC) system to deliver chemotherapeutic doxorubicin oxygen for enhanced cancer chemo-immunotherapy. TAMs-targeting depletion hypoxia alleviation synergistically reprogram the tumor immu...