background: investigators frequently encounter continuous outcomes with plenty of values clumped at zero called semi-continuous outcomes. the gensini score, one of the most widely used scoring systems for expressing coronary angiographic results, is of this type. the aim of this study was to apply two statistical approaches based on the categorization and original scale of the gensini score to ...

Coronary artery disease (CAD) is a major cause of morbidity and mortality worldwide. Each year, an estimated 635,000 Americans have a new coronary attack (defined as first hospitalized myocardial infarction (MI) or coronary heart disease related death) and 280,000 have a recurrent attack [1]. Coronary artery ectasia (CAE) is a relatively common entity but its prevalence and relevance are not as...

  Introduction: Aortic valve sclerosisis considered as a manifestation of coronary atherosclerosis. Recent studies demonstrated an association between aortic valve sclerosis and obstructive coronary artery disease. The purpose of this study was to evaluatethe correlation betweenaortic valve sclerosis andobstructive coronary artery disease and the extent of coronary artery disease in patients ho...

CONTEXT The 2011 American Heart Association guidelines identified pregnancy complications as a risk factor for cardiovascular disease in women. However, miscarriage was not mentioned within the guidelines, and there is no consensus on the association between miscarriage and future risk of cardiovascular disease. OBJECTIVE To confirm or refute the association, a meta-analysis of published pape...

psychological problems play a critical role in development of cardiovascular disease. several mechanisms were suggested to explain the association and mechanism of this effect, recently. knowledge of the mechanisms mediating the association between psychological status and heart disease could help in developing treatments. the effects of mind and mood on the cardiovascular system can be due to ...

materials and methods in this case-control study, using the polymerase chain reaction (pcr), adrs266729 and rs2241766 gene polymorphisms were genotyped in b-type ultrasonography-proven nafld patients, with (n = 246) or without (n = 247) cad and in healthy controls (n = 304). serum lipid profiles were determined using biochemical methods. statistical analyses were performed using spss 17.0 stati...

Chronic granulomatous disease (CGD) is a primary immunodeficiency characterized by recurrent, life-threatening bacterial and fungal infections of the skin, airways, lymph nodes, liver, brain, bones. These most commonly occur in organs contact with outside world (lungs, gastrointestinal tract, skin), as well nodes that drain these structures. While involvement can be seen many organs, there no k...

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results the prevalence’s of aa, ac and cc genotypes were 55.2%, 24.1% and 20.7% in cad patients and 51.6%, 40.9% and 7.5% in the control subjects, respectively. the frequencies of the c allele were significantly higher in cad patients compared with control groups (p < 0.05). logistic regression analysis revealed a significant association between the c allele and the risk of cad (or = 1.61, 95%c...

background: it is hypothesized that the impacts of life events accumulate and can trigger and promote atherosclerosis in susceptible individuals. in the current study, the correlation of total life stressors during 1 year was investigated relative to coronary artery disease (cad). methods: the study population consisted of 148 males and 152 females aged 35–76 years. the subjects were classified...