Background: β-thalassemia is the most common hereditary disease in Iran, and more than 2 million carriers of β-thalassemia live in Iran. On the other hand, our country is located in the thalassemia belt, and no comprehensive study has been conducted regarding the effect of erythropoietin on blood parameters in thalassemia intermedia patients in our region. Therefore this study aimed to investig...

Currently many patients with chronic renal failure have profited from the use of erythropoietin to correct anemia (1,2). In chronic kidney disease, anemia is believed to be a surrogate index for tissue hypoxia that continues preexisting renal tissue injury (1-3). Erythropoietin is an essential glycoprotein that accelerates red blood cell maturation from erythroid progenitors and facilitates ery...

The goal of the present study was to determine the minimum concentration of systemic erythropoietin-R76E required for neuroprotection in the retina. Erythropoietin (EPO) exhibits neuroprotective effects in both in vitro and in vivo models of neuronal cell death although its classical function is the regulation of red blood cell production. It can cross the blood brain barrier and therefore can ...

(juirements.’ Changes in need are met in part by changes in the circulating red cell mass. Accordingly, erythropoietin has been demonstrated in the urine and plasma of patients with anemia or polycythemia of varying origin. However, investigations relating erythropoietin to erythropoiesis in normal mdividuals have only recently been made possible by improved assay methods. This study was undert...

By WARD D. N0YE5, BILL M. DO st AND LoRErrA C. Wails T HE RATE of red cell production is regulated by a plasma factor( s ) termed erythropoietin. While injection of exogenous plasma rich in this substance (or substances ) has been shown to induce an increase in the total circulating red cell mass by stimulation of erythropoiesis,13 quantitation of erythropoietin has been hampered by lack of spe...

............................................................................................................................. ii Acknowledgements .......................................................................................................... iv List of Figures .................................................................................................................. vii List o...

Nephrocalcinosis: another cause of renal erythrocytosis Although erythrocytosis is not a recognised complication of nephro-calcinosis, in the course of a study of 250 patients with nephro-calcinosis we found nine patients with raised blood haemoglobin concentration and haematocrit value. All patients had radiological medullary nephrocalcinosis, of varying underlying cause (two primary hyperpara...

By WARD D. N0YE5, BILL M. DO st AND LoRErrA C. Wails T HE RATE of red cell production is regulated by a plasma factor( s ) termed erythropoietin. While injection of exogenous plasma rich in this substance (or substances ) has been shown to induce an increase in the total circulating red cell mass by stimulation of erythropoiesis,13 quantitation of erythropoietin has been hampered by lack of spe...

By WARD D. N0YE5, BILL M. DO st AND LoRErrA C. Wails T HE RATE of red cell production is regulated by a plasma factor( s ) termed erythropoietin. While injection of exogenous plasma rich in this substance (or substances ) has been shown to induce an increase in the total circulating red cell mass by stimulation of erythropoiesis,13 quantitation of erythropoietin has been hampered by lack of spe...