We compared clinicopathological characteristics of colorectal polyps, in order to investigate the hypothesis of neoplastic transformation of hyperplastic polyps. Of 4723 colonoscopies performed in our department over four years, 22 patients with 23 mixed hyperplastic polyps (MHAP) were found. These were compared with 61 patients with 86 hyperplastic polyps, 40 with 58 tubular adenomas and 27 wi...

Two monoclonal antibodies (LN-4, LN-5) reactive to human macrophages in B5 formalin-fixed, paraffin-embedded tissue sections have been produced by using deparaffinized cell extracts of peripheral blood mononuclear cells. Both monoclonal antibodies were initially identified on paraffin-embedded sections of hyperplastic lymph nodes by using the immunoperoxidase staining procedure. Specificity scr...

Diagnosis of peripheral oral exophytic lesions might be quite challenging. This review article aimed to introduce a decision tree for oral exophytic lesions according to their clinical features. General search engines and specialized databases including PubMed, PubMed Central, Medline Plus, EBSCO, Science Direct, Scopus, Embase, and authenticated textbooks were used to find relevant topics by m...

BACKGROUND & AIMS Obesity and diabetes mellitus are associated with an increased incidence of proximal colon cancer. Colonic adenoma that has been reported to be associated with elevated serum insulin levels and subsets of hyperplastic polyps might serve as a precursor of colon cancer. In this study, we sought to determine segment-specific associations between serum insulin levels and the preva...

Histologic grading schemes for canine inflammatory conditions are sparse, and in the case of the canine pancreas, have not been previously described. In a previous study, we determined that histologic lesions of the exocrine pancreas occurred much more frequently than gross lesions. The intention of the current study was to develop a histologic grading scheme for nonneoplastic lesions following...

BACKGROUND/AIMS In vivo autofluorescence endoscopic imaging and spectroscopy have been used to detect and differentiate benign (hyperplastic) and preneoplastic (adenomatous) colonic lesions. This fluorescence is composed of contributions from the epithelium, lamina propria, and submucosa. Because epithelial autofluorescence in normal and diseased tissues is poorly understood, this was the focus...

Hyperplastic polyps are lesions that are mostly smaller than 1 cm; they are sessile and innocuous. They develop as a result of tissue damage and an exaggerated mucosal regeneration. Intestinal metaplasia and dysplasia at a rate of 1–20% may be seen in hyperplastic polyps. However, the risk of carcinoma development is less than 2%. The risk increases in multiple polyps (1). Here we present a cas...

Background and aims: Colorectal adenomas are recognised as precursors of colorectal carcinomas. The significance of hyperplastic (metaplastic) colorectal polyps is unknown. The relationship between hyperplastic polyps and adenomas, and the prevalence and incidence of these lesions were evaluated in individuals predisposed to familial colorectal cancer. Methods: A total of 299 individuals partic...