The RDX gene anchors cytoskeletal actin of stereocilia to hair cell transmembrane and is responsible for autosomal recessive nonsyndromic hearing impairment (ARNSHI) due to DFNB24. A genome scan was performed using DNA samples from a consanguineous Pakistani family with ARNSHI. A significant maximum two-point LOD score of 4.5 (θ = 0) and multipoint LOD score of 5.8 were achieved at marker D11S1...

Estimation of the amounts of residues resulting from high-order detonation of munitions is complicated by the presence of residues from previous detonations and the inability to easily obtain adequately-sized samples to overcome spatial heterogeneity in residue deposition. This study was conducted to assess the use of snow-covered ranges to provide these types of estimates. Specifically, snow-c...

The aliphatic nitramine 4-nitro-2,4-diazabutanal (NDAB; C2H5N3O3) is a ring cleavage metabolite that accumulates during the aerobic degradation of the energetic compound hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) by various Rhodococcus spp. NDAB is also produced during the alkaline hydrolysis of either RDX or octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) and during the photolysis of...

Constitutive relationships in the crystalline energetic material -cyclotrimethylenetrinitramine -RDX have been investigated using first-principles density functional theory. The equilibrium properties of -RDX including unit cell parameters and bulk modulus, as well as the hydrostatic equation of state EOS , have been obtained and compared with available experimental data. The isotropic EOS has ...

The development of effective treatment options for munitions contaminants is essential for Department of Defense live fire range management and sustainability. The energetic compounds 2,4,6-trinitotoluene (TNT) and hexahydro-13,5-trinitro-1,3,5-triazine (RDX) have been identified in range soil. Alkaline hydrolysis, initiated through treatment with lime, has been shown to effectively destroy the...

Adsorption to GAC is an effective ·method for removing high explosives (HE) compounds from water, but no permanent treatment is achieved. Bioregeneration, which treats adsorbed contaminants by desorption and biodegradation, is being developed as a method for reducing GAC usage rates and permanently degrading RDX and HMX. Because desorption is often the limiting mass transfer mechanism in bioreg...

A quantum-mechanically-based potential energy function that describes interactions of dimers of the explosive cyclotrimethylenetrinitramine (RDX) is used to predict polymorphic structures of crystalline RDX. The potential was first used in crystal structure prediction methods which generate polymorphs of RDX and provide a 0 K ordering in energy. The 13 low energy-structures generated by crystal...

In previous work, we found that an anaerobic sludge efficiently degraded hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), but the role of isolates in the degradation process was unknown. Recently, we isolated a facultatively anaerobic bacterium, identified as Klebsiella pneumoniae strain SCZ-1, using MIDI and the 16S rRNA method from this sludge and employed it to degrade RDX. Strain SCZ-1 degrad...

Radixin (RDX) is part of the ezrin-radixin-moesin (ERM) protein family. It functions as a membrane-cytoskeletal linker in actin-rich cell surface structures and is thought to be essential for cortical cytoskeleton organization, cell motility, adhesion, and proliferation. An increase in phosphorylated ERM in fibroblast-like synoviocytes contributes to rheumatoid arthritis (RA) synovial hyperplas...

Soils in Technical Area 16 at Los Alamos National Laboratory (LANL) are severely contaminated from past explosives testing and research. Our objective was to conduct laboratory and pilot-scale experiments to determine if zerovalent iron (Fe(0)) could effectively transform RDX (hexahydro-1,3,5-trinitro-1,3,5-triazine) in two LANL soils that differed in physicochemical properties (Soils A and B)....