Main results 16 RCTs met the selection criteria. Antihypertensive drugs were more effective than placebo for reducing the risk of TCEs (3 RCTs), all cause mortality (1 RCT), and MEPs (3 RCTs) (table). A target diastolic BP of 80 compared with 90 mm Hg reduced risk of TCEs (relative risk reduction [RRR] 51%, 95% CI 22 to 86)(1 RCT); a target BP of 150/85 compared with 180/105 mm Hg reduced risk ...

The three-report review was aimed at describing the historical development of clinical trials, controlled trials (CT) and randomized (RCT), inclusion these experimental approaches in disciplines related to both health individuals populations (medicine epidemiology). In Report 1, authors consider terminology issues applied CT RCT, sources involved concepts, relevant disciplines. It shown that te...

BACKGROUND Factors influencing patients' motivations for enrolling in, and their experiences of, orthopaedic randomized controlled trials (RCTs) are not fully understood. Less is known about healthcare professionals' (HCP) experiences of RCT involvement. AIM This study investigates patients' and HCPs' views and experiences of RCT participation and delivery to inform the planning of future RCT...

The double-blind randomized controlled trial (RCT) is accepted by medicine as objective scientific methodology that, when ideally performed, produces knowledge untainted by bias. The validity of the RCT rests not just on theoretical arguments, but also on the discrepancy between the RCT and less rigorous evidence (the difference is sometimes considered an objective measure of bias). A brief ove...

Background/Aim. Root canal treatment (RCT) is one of the most common endodontic procedures for which patients visit dentist. Patient's knowledge, awareness, and attitude regarding root are an interesting problem in everyday dentistry. Therefore, study aimed to evaluate coming treatment. Methods. Questionnaire surveys were carried out a group 209 patients, including queries characterizing their ...

background: considering the ease of administration of capecitabne instead of infusional 5fu for concurrent  radiochemotherapy (rct) of rectal cancer, the use of capecitabine has increased significantly in our radiation oncology department in the past years. thus we decided to compare the safety and survival with these 2 drugs by a retrospective review. methods: files of all patients receiving r...

BACKGROUND This paper proposes the use of decision trees as the basis for automatically extracting information from published randomized controlled trial (RCT) reports. An exploratory analysis of RCT abstracts is undertaken to investigate the feasibility of using decision trees as a semantic structure. Quality-of-paper measures are also examined. METHODS A subset of 455 abstracts (randomly se...

BACKGROUND Randomized controlled trials (RCT) are limited by their generalizability to the broader nontrial population. To provide a context for Acute Study of Nesiritide in Decompensated Heart Failure (ASCEND-HF) trial, we designed a complementary registry to characterize clinical characteristics, practice patterns, and in-hospital outcomes of acute heart failure patients. METHODS AND RESULT...

BACKGROUND Estimates of life expectancy are a key input to cost-effectiveness analysis (CEA) models for cancer treatments. Due to the limited follow-up in Randomized Controlled Trials (RCTs), parametric models are frequently used to extrapolate survival outcomes beyond the RCT period. However, different parametric models that fit the RCT data equally well may generate highly divergent predictio...