BACKGROUND In recent years, several studies have correlated pitch count with an increased risk for injury among baseball pitchers. However, no studies have attempted to draw a similar conclusion based on number of carries by running backs (RBs) in football. PURPOSE To determine whether there is a correlation between number of carries by RBs in the National Football League (NFL) and risk of in...

Genetic sequences ported into non-native hosts for synthetic biology applications can gain unexpected properties. In this study, we explored sequences functioning as ribosome binding sites (RBSs) within protein coding DNA sequences (CDSs) that cause internal translation, resulting in truncated proteins. Genome-wide prediction of bacterial RBSs, based on biophysical calculations employed by the ...

Las conexiones precalificadas viga-columna desempeñan un rol crítico en el comportamiento de las estructuras acero; ellas depende adecuado del sistema estructural seleccionado pues permiten al disipar energía eventos sísmicos por medio deformaciones inelásticas, lo cual presente artículo se muestra la implementación numérica software libre SEDE CONNECTION (Seismic Design Connection), uso educat...

BACKGROUND Roberts syndrome (RBS) is a rare genetic disorder characterized by craniofacial abnormalities, limb malformation, and often severe mental retardation. RBS arises from mutations in ESCO2 that encodes an acetyltransferase and modifies the cohesin subunit SMC3. Mutations in SCC2/NIPBL (encodes a cohesin loader), SMC3 or other cohesin genes (SMC1, RAD21/MCD1) give rise to a related devel...

Softening of beams near the moment connection can be regarded as one most convenient methods for retrofitting non-seismically designed buildings. This done by drilling beam web (aka RWS–Reduced Web Section) or cutting flanges RBS–Reduced Beam Section). Thus, becoming a cost-effective option and erection new buildings, while optimising use steel; making this high environmental impactful material...

Whole cell patch-clamp recordings from GABAergic cells of thalamic reticular nucleus (RTN) in thalamocortical slices made from postnatal day 6 (P6) to 10 (P10) were used to investigate the pattern of rebound bursts (RBs) triggered by an injection of hyperpolarizing current into RTN cells. The number of RBs in the RTN and the overlying Na(+)/K(+) spikes changed in an age-dependent manner. The ge...

Globally eliminating measles using available vaccines is biologically feasible because the measles virus (MV) hemagglutinin (H) protein is antigenically stable. The H protein is responsible for receptor binding, and is the main target of neutralizing antibodies. The immunodominant epitope, known as the hemagglutinating and noose epitope, is located near the receptor-binding site (RBS). The RBS ...

The human developmental diseases Cornelia de Lange Syndrome (CdLS) and Roberts Syndrome (RBS) are both caused by mutations in proteins responsible for sister chromatid cohesion. Cohesion is mediated by a multi-subunit complex called cohesin, which is loaded onto chromosomes by NIPBL. Once on chromosomes, cohesin binding is stabilized in S phase upon acetylation by ESCO2. CdLS is caused by heter...

Abstract. Recognition of a new angular unconformity and the synthesis detrital zircon U–Pb (U–Th) / He provenance records, including double dating, from NW Zagros region elucidate basin dynamics foreland wedge-top intermontane units, as well tectonic processes in source terranes response to different geodynamic phases. In this contribution, we present field observations data hinterland basins r...