In the recent article by Broch et al. (1), circulating retinol-binding protein-4 (RBP4) (measured by nephelometry) was not correlated with adiposity or insulin sensitivity; however, negative correlations with indexes of insulin secretion were detected. The authors concluded that RBP4 may impair -cell function in human subjects. This is an interesting hypothesis, particularly because retinol see...

Purpose This study aims to quantify the concentration of apolipoprotein A1 (APOA1) and retinol binding protein (RBP4) expressed in the vitreous humors of patients with rhegmatogenous retinal detachment associated with choroidal detachment (RRDCD), rhegmatogenous retinal detachment (RRD), and idiopathic epimacular membrane (IEM). This study also aims to investigate the potential role of APOA1 an...

BACKGROUND Retinol-binding protein 4 (RBP4) may play an important role in the origin of insulin resistance and metabolic syndrome. Few prospective data are available on the relationship between RBP4 and coronary heart disease (CHD). Furthermore, previous studies did not distinguish among full-length and truncated forms of RBP4 that might have various biological activities. METHODS AND RESULTS...

Fenofibrate is a peroxisome proliferator-activated receptor-alpha (PPARalpha) activator that has been clinically used to treat dyslipidemia and insulin resistance. To better understand the molecular mechanisms underlying fenofibrate action, we investigated whether fenofibrate affects serum levels of retinol-binding protein-4 (RBP4), an adipocytokine that has recently been shown to link obesity ...

OBJECTIVE Retinol-binding protein 4 (RBP4) is a recently identified adipokine that is elevated in the serum in several insulin-resistant states. We investigated the relationship between non-alcoholic fatty liver disease (NAFLD) and serum RBP4 in nondiabetic adults. METHODS One hundred and fifty-nine nondiabetic, non-alcoholic subjects (95 males and 64 females) participated in this study. Divi...

Objective The main purpose of the current study was to investigate the association between QTc and various insulin sensitive or insulin resistant adipocytokines such as leptin, adiponectin, RBP4, and PAI-1 as well as inflammatory markers, oxidative stress and endothelial function in patients with type 2 diabetes. Method QTc, blood and urine tests were performed in 101 type 2 diabetic patients h...

BACKGROUND The interplay between the novel adipokine retinol-binding protein-4 (RBP4) and coronary artery disease (CAD) is still obscure. We investigated the relationship between RBP4 levels and the presence and severity of angiographically proven CAD and determined its possible role in acute myocardial infarction (AMI). METHODS 305 individuals with angiographically proven CAD (CAD-patients),...

Pro-inflammatory cytokines play a vital role in periodontitis, obesity and chronic diseases. Retinol binding protein 4 (RBP4), novel adipokine has been implicated as pro-inflammatory marker other systemic In periodontal disease, RBP4 correlated with markers of low-grade inflammation. can directly induce the production mediators involved leukocyte recruitment adherence, including vascular cell a...

OBJECTIVE We evaluated associations of serum retinol-binding protein 4 (RBP4) with subclinical cardiovascular disease (CVD). RESEARCH DESIGN AND METHODS Subclinical CVD was measured with echocardiography, carotid artery ultrasound, brachial artery ultrasound, and invasive forearm endothelial vasoreactivity in 1,008 70-year-old participants (50% women) of the Prospective Investigation of the V...

The association of retinol binding protein 4 (RBP4) with atherosclerosis of the carotid artery in type 2 diabetes mellitus (T2DM) remains undefined. We aimed to investigate the correlation of RBP4 expression with atherosclerosis of the carotid artery in T2DM. A total of 1,076 subjects were investigated for intima-media thickness of the bilateral common carotid arteries, and they were divided in...