Poorly water-soluble drugs frequently solubilize into bile colloids and this natural mechanism is key for efficient bioavailability. We tested the impact of pharmaceutical polymers on solubilization interplay using proton nuclear magnetic resonance spectroscopy, dynamic light scattering, by assessing flux across model membranes. Eudragit E, Soluplus, a therapeutically used polymer, Colesevelam,...

In this chapter we survey asset pricing in dynamic economies with heterogeneous, rational traders. By ‘rational’ we mean traders whose decisions can be described by preference maximization, where preferences are restricted to those which have an subjective expected utility (SEU) representation. By ’heterogeneous” we mean SEU traders with different and distinct payoff functions, discount factors...

Matrix functions are a central topic of linear algebra, and problems of their numerical approximation appear increasingly often in scientific computing. We review various rational Krylov methods for the computation of large-scale matrix functions. Emphasis is put on the rational Arnoldi method and variants thereof, namely, the extended Krylov subspace method and the shift-and-invert Arnoldi met...

SYSTEMATIC REVIEW SOURCE This is a rational clinical examination abstract, a regular feature of the Annals’ Evidence-Based Emergency Medicine (EBEM) series. Each features an abstract of a rational clinical examination review from the Journal of the American Medical Association and a commentary by an emergency physician knowledgeable in the subject area. The source for this rational clinical exa...

This paper studies general equilibrium with private and incomplete state verification. All trade is agreed ex ante, that is, before private information is received. Agents buy lists of bundles that give them the right to receive one of the bundles. With rational expectations, that is, knowledge of the selection mechanism, agents can predict which bundle will be delivered in each state of nature...