Pigmentation defects are common in the inherited disease type 1 neurofibromatosis (NFl), predicting a role for the NFl gene product, neurofibromin, in the skin. We used immunohistochemistry to determine the distribution of neurofibromin in normal developing and adult rat skin, normal neonatal and adult human skin, and skin from patients affected with NFL The distribution of NFl mRNA in the epid...

The absorption of undiluted phthalate diesters [dimethyl phthalate (DMP), diethylphthalate (DEP), dibutyl phthalate (DBP) and di-(2-ethylhexyl)phthalate (DEHP)] has been measured in vitro through human and rat epidermal membranes. Epidermal membranes were set up in glass diffusion cells and their permeability to tritiated water measured to establish the integrity of the skin before the phthalat...

BACKGROUND AND OBJECTIVE Our previous histological studies indicated that near-infrared (NIR) irradiation stimulates collagen proliferation in rat and human skin for 3 months. High collagen density in the dermis and smoothing of the epidermis were observed in irradiated rat skin, and appeared to last up to 6 months. Epidermal smoothness in irradiated rat skin seems to resemble scarring. Here, w...

HIV/AIDS Drugs In article 2203198, Garry Laverty and co-workers develop a long-acting injectable drug delivery implant composed of short peptide sequence attached to the zidovudine. Upon injection, this aqueous solution-based formulation rapidly forms drug-releasing hydrogel in response phosphatase enzymes present within skin space. Clinically relevant concentrations zidovudine were delivered r...

PURPOSE This study was conducted to assess the effect of skin pre-treatment with Transcutol(®) and eucalyptus oil on systemic absorption of topical trolamine salicylate in rat. METHODS Pharmacokinetic parameters of salicylic acid following administration of trolamine salicylate on rat skin pre-treated with either Transcutol(®) or eucalyptus oil were determined using both non-compartmental and...

introduction: with regarding the positive effects of low power gallium aluminium arsenid laser (laser) on some muscloskeletal disorders in this investigation effects of laser on open skin full thickness wound in rat by histological and biomechanical methods were evaluated. materials & methods: 46 male sprague dawley rats randomly divided into control and experimental groups. under general anaes...

Introduction: In recent study both endothelium-dependent and endothelium-independent mechanisms have been reported for the action of β-adrenoceptor. The aim of this study was to investigate on the role of nitric oxide (NO) and cyclic guanosin monophosphate (cGMP) in vasodilation mechanisms of β2-adrenoceptors (β2-AR) in rat skin vessels. Methods: All drugs were injected subcutaneous into p...

Background: Ovarian tissue cryopreservation and autotransplantation is the only fertility preservation way for prepubertal girls and situations that cytotoxic treatment is urgent. Materials and Methods: The ovaries of premature (5 weeks old) rats were autografted under cervical skin after vitrification. 3 weeks later, transplanted ovaries were removed from the body and structure of ovary, expre...