In this issue of The EMBO Journal, Wilson et al (2012) elegantly discovered an important new axis for intestinal homeostasis and cancer, using an RNAi screen to enhance the RAS-induced multivulva (MUV) phenotype in Caenorhabditis elegans.

UNLOCKING THE MYSTERY of the brain renin-angiotensin system (RAS) and its role in cardiovascular physiology has been a theme for state-of-the-art research for 30 years. Each time a new, more precise tool becomes available, the problem is revisited. In this release of Physiological Genomics, Sinnayah et al. (24) present a report on a new way to analyze the role of specific genes in specific card...

OBJECTIVE The aim of this study was to identify the incidence of atherosclerotic renal artery stenosis (RAS) in patients with peripheral vascular disease (PVD) and its relation to any known risk factors. SUBJECTS AND METHODS This prospective study was conducted on 212 patients who were subjected to peripheral angiography for symptoms of PVD over a 3-year period from 1995 to 1998 at the Mubara...

The classical renin–angiotensin system (RAS) is activated by renin that is secreted from the juxtaglomerular cells of the afferent arteriole, which cleaves angiotensinogen (Agt), synthesized and released by the liver. This leads to the generation of a potent biologically active peptide, angiotensin II (AngII), which contributes to blood pressure regulation and sodium homeostasis. Recent studies...

Since the declaration of war on cancer more than 40 years ago, progresses on cancer treatment outcomes have been slow and limited for most part, despite major investments in research and development. However, the realization that cancer is an extremely complex and heterogeneous mixture of diseases, coupled with technological advances in cancer genomics, proteomics, and metabolomics, has led to ...

Several interesting studies in the literature have demonstrated that a temporal interval coinciding with or following a rapid sequence of auditory stimuli is subjectively lengthened relative to a baseline interval without such rapid auditory stimulation (RAS). It has also been found that an interval preceding RAS is subjectively shortened. These effects have been attributed to acceleration of a...

recurrent aphthous stomatitis (ras) is known as the most common chronic disease of the oral cavity, which affects a range of 5-25% of the population. ras appears to be associated with some human leukocyte antigen (hla) class ii alleles and haplotypes. this study attempts to survey the distribution of hla-drb and -dqb alleles among iranian ras patients and healthy controls. in order to evaluate ...

a new article published in the journal Aging, Borras et al. report that Ras-GRF1 homozigous deletion increases both median and maximum longevity in laboratory mice [1]. The human Ras, superfamily now counts more than 150 different proteins subdivided into five different protein families: Ras, Rho, Rab, Arf and Ran. These protein families regulate many cellular processes [2] including cellular d...