Descending projections arising from brainstem serotonergic (5HT) neurons contribute to both facilitatory and inhibitory controls of spinal cord "pain" transmission neurons. Unclear, however, are the brainstem networks that influence the output of these 5HT neurons. To address this question, here we used a novel neuroanatomical tracing method in a transgenic line of mice in which Cre recombinase...

Various studies have implicated the involvement of noradrenaline (NA) and/or serotonin (5-hydroxytryptamine (5-HT)) in the pathogenesis and treatment of depression. The aim of the present study was to investigate the effects of acute and 7 days of administration of desipramine, a NA re-uptake inhibitor, on the rate of 5-HT synthesis in the rat brain. The study was done by an autoradiographic me...

Involvement of the caudal raphe nuclei (raphe pallidus, RPa; raphe magnus, RMg, and raphe obscurus, ROb) in feeding behavior of adult rats was studied by measuring c-Fos protein expression, in animals submitted to the "meal-feeding" model of food restriction in which the rats were fed ad libitum only from 7:00 to 9:00 h, for 15 days. The experimental groups submitted to chronic fasting, named '...

To investigate the release profile of met-enkephalin, β-endorphin, and dynorphin-A in ruminants' CNS, goats were stimulated by electroacupuncture of 0, 2, 40, 60, 80, or 100 Hz for 30 min. The pain threshold was measured using potassium iontophoresis. The peptide levels were determined with SABC immunohistochemisty. The results showed that 60 Hz increased pain threshold by 91%; its increasing r...

This work addressed the study of subnucleus reticularis dorsalis (SRD) neurons in relation to their supraspinal input and the spinal terminating sites of their descending axons. SRD extracellular unitary recordings from anesthetized cats aimed to specifically test, 1) the rostrocaudal segmental level reached by axons of spinally projecting (SPr) neurons collateralizing or not to or through the ...

seems to be original. This goes to show that the human foetus exhibits signs of animation parallel with those of bodily configuration. In significance and purpose Albertus' observation is, therefore, far removed from Harvey's ideas, although the method is the same. It is not unlikely that Harvey was familiar with Albertus' text in which comparative embryology was treated on a broad Aristotelian...

This report describes a study project done at the Rudolf Magnus Institute (RMI) in the eld of neural network development. The goal of this study is to develop a neural network that is able to automatically classify rat behaviour from video. This project was started because of the great di erences in perception and classi cation of rat behaviour between human observers. Chapter 1 consists of a g...

We investigate the e¤ect of employee heterogeneity on the incentive to put forth e¤ort in a market-based tournament. Employers use the tournament’s outcome to estimate employees’ abilities and accordingly condition their wage o¤ers. Employees put forth e¤ort, because by doing so they increase the probability of outperforming the rival, thereby increasing their ability assessment and thus the wa...

Are fairness concerns of relevance to environmental economics and, if so, are they sufficiently structured to improve analysis in this field? On both of these questions, we answer in the affirmative, arguing that people’s fairness views are based on both general rules and the context, where context refers to the set of variables and persons employed to interpret and apply the principles. The fa...