The three-report review was aimed at describing the historical development of clinical trials, controlled trials (CT) and randomized (RCT), inclusion these experimental approaches in disciplines related to both health individuals populations (medicine epidemiology). In Report 1, authors consider terminology issues applied CT RCT, sources involved concepts, relevant disciplines. It shown that te...

background corticosteroids are used to induce remission in auto-immune hepatitis. they are not universally effective; therefore, alternative treatments are needed. in this study cysclosporine-a has been compared with prednisolone as an alternative treatment in a randomized controlled trial. this paper is an interim analysis of an ongoing clinical trial. methods sixteen years and older consentin...

BACKGROUND Symptomatic femoroacetabular impingement (FAI) is currently corrected by surgery. However, it is possible that nonsurgical treatment could resolve symptomatic FAI in some patients; thus, uncertainty about the necessity of surgical treatment exists. The current equipoise concerning FAI treatment presents an opportunity to conduct a randomized controlled trial (RCT) of surgical and non...

nystatin oral suspension is a safe firstline therapy; fluconazole is more effective (strength of recommendation [sor]: B, 1 small randomized controlled trial [rCT]) but has not been approved by the Food and Drug Administration (FDA) for use in immunocompetent infants. Miconazole oral gel is also more effective than nystatin suspension, but is not commercially available in the united states (sor...

Prescription and adherence to medical therapy for heart failure are disappointing despite convincing randomized controlled trial (RCT) evidence for angiotensin-converting enzyme inhibition, beta-blockade, and aldosterone antagonism. In this study, we report an imbalanced approach amongst clinicians, who describe focusing during patient consultations on perceived risks of therapy rather than sur...

Abstract This paper aims at describing the process for assessing intervention fidelity of a randomized controlled trial (RCT) an “Adolescent Coping with Depression Course” (ACDC) and to assess participants’ satisfaction intervention. We applied comprehensive model developed by National Institutes Health’s Behavior Change Consortium examine how our met requirements under five categories. Data ca...

Medical science recognizes that patients do not always respond to treatment in a way physicians expect; moreover, different people and sometimes unpredictable ways. These differences can be attributed observable patients’ characteristics, such as age gender, but also unobservable characteristics influence the results, lifestyle or an unreported health condition. To overcome this problem, during...

Introduction: Higher levels of pro-inflammatory cytokines in schizophrenia have suggested that dysfunctions of the immune system may play a role in this disabling condition. The current study was performed to discover if low dose celecoxib combined with clozapine may improve symptoms of schizophrenia or not. Methods:<span...