Abstract Glioblastoma multiforme (GBM) is an incurable aggressive brain cancer in which current treatment strategies have demonstrated limited survival benefit. In recent years, nitrogen-containing bisphosphonates (N-BPs) direct anticancer effects a number of tumour types including GBM. this study, nano-formulation with the RALA peptide was used to complex N-BP, alendronate (ALN) into nanoparti...

Climate change adaptation is currently an important community concern in developing countries like Bangladesh. The conceptualization of within the government system matters for promotion activities such as employment generation local communities. lesser gap between policy and community’s needs more effective outcomes are ensuring success promoting sustainable livelihoods or vice versa. This int...

The angiotensin II type 1 receptor (AT1R) plays an important role in cardiovascular function and as such represents a primary target for therapeutic intervention. The AT1R has traditionally been considered to be coupled to the activation of phospholipase C (PLC) via its association with G q/11, leading to increases in intracellular inositol phosphate (IP) and release of calcium from intracellul...

The minimal supersymmetric standard model (MSSM), is perhaps the leading candidate for new physics beyond the standard model, but it encounters difficulties with string gauge unification and in addition does not shed any light on the question of fermion masses. We consider a scenario in which the MSSM is valid up to an energy scale of ∼ 10 16 GeV, but that above this scale the theory is supplem...