Bone metastases, which are commonly seen in patients with advanced cancers, are a major cause of skeletal events, disability, and death. Radium-223 dichloride (radium-223; Xofigo, formerly Alpharadin), a first-in-class, alpha-emitting radiopharmaceutical that selectively targets bone metastases with high-energy short-range alpha-particles, has been approved for the treatment of patients with ca...

milligram. As representatives in the British Empire "of the Radium Beige (Union Miniere du Haut Katanga), we would like to have an opportunity of correcting this statement. Previous to the discovery of the rich ores in the Belgian Congo, the standard price for radium element was $110 per milligram, and this price was reduced following the production of radium from the Congo ore to $70, equivale...

  ABSTRACTBackground : The presence of primordial radionuclide in human habitats has always been a source of prolonged exposure. Measurement of naturally occurring radionuclides in the environment can be used as baseline to evaluate the impact of non-nuclear activities and also routine releases from nuclear installations.   Materials and methods: A total of 56 samples from 18 different foodstuf...

ABSTRACT Background: The radiological impact of the use of phosphate fertilizers in soil is due to the internal irradiation of the lung by the alpha particles, short lived radon-thoron progeny and the external irradiation of the body by gamma rays emitted from radionuclides in situ. This paper describes the results of gamma spectrometric measurements of the concentration ...

In 1936, almost 4 decades after the discovery of the x-ray and of radium, the German Röntgen Society erected a monument to commemorate all who had died as a consequence of exposure to x-rays or radium. George W.C. Kaye of the US National Physical Laboratory wrote the inscription: “To the röntgenologists and radiologists of all nations, doctors, physicists, chemists, technical workers, laborator...

Metastatic castration-resistant prostate cancer (mCRPC) frequently metastasizes to the bone, often resulting in painful skeletal events, reduced quality of life, and reduced survival. The beta-emitting radiopharmaceuticals strontium-89 and samarium-153 alleviated pain in mCRPC patients with widespread skeletal metastases and have been associated with myelotoxicity. Radium-223, a first-in-class ...

INTRODUCTION A number of drugs have been shown to extend life expectancy in castration-resistant prostate cancer (CRPC). Skeletal related events (SREs) secondary to bone metastases cause significant morbidity for men with CRPC. The α-emitting radiopharmaceutical radium-223 dichloride has been shown to improve overall survival, time to symptomatic skeletal events (SSEs) and quality of life in CR...

After practicing medicine for two years, he entered graduate school and in May 2005 received his Ph.D. in Biochemistry and Molecular Genetics at the University of Alabama at Birmingham. He is currently a research associate at the University of Wisconsin-Madison. He is the recipient of the American Medical Association's Physican's Recognition Award and was also recipient of the Outstanding Gradu...

Amount of pollution radiation in foodstuffs and feedstuffs are very necessary to measure because it is a direct contact with human animal health. Therefore, the present investigation useful for health environmental data base. The study included measurement effective radium-226 content (CRa) some chosen samples vegetables fruits (local imported) Najaf governorate. CRa were measured using Solid S...

INTRODUCTION Approximately 10 - 20% of prostate cancer cases ultimately progress to castration-resistant prostate cancer (CRPC), for which there is a poor prognosis and a therapeutic need. Radium-223 dichloride (radium-223 [Xofigo]) is a first-in-class α-emitting radiopharmaceutical shown to significantly prolong overall survival in patients with CRPC with symptomatic bone metastases and no vis...