Research is currently focused on maximizing cancer cell death while minimizing harm to healthy cells. Gold nanoparticles (GNPs) have been extensively studied as a radiosensitizer improve sparing normal tissue. Previous research and simulations demonstrated that the presence of single GNP increases DNA damage dose. In this study, Monte Carlo simulation using Geant4-DNA code was used investigate ...

Abstract Developing and evaluating potential radiosensitisers to enhance therapeutic efficacy are urgently needed due the lack of efficient chemotherapy for meningioma. Histone deacetylase (HDACs) expression is generally increased in many cancer types regulate numerous proteins involved tumorigenesis. Targeting HDAC using inhibitor (HDACi) represent promising that affect various biological proc...

Introduction: In the present study, AS1411 aptamer conjugated gold nanoclusters (GNCs) have been introduced as a targeted radiosensitizer for enhancing megavoltage radiation therapy efficacy. RT has identified as an effective therapeutic modality for many different types of solid tumors. However, equal radiation beams absorption by tumor and surrounding healthy tissues is still...