نتایج جستجو برای: radioimmunotherapy rit

تعداد نتایج: 1820  

2017
In Ho Song Youn Noh Junhye Kwon Jae Ho Jung Byung Chul Lee Kwang Il Kim Yong Jin Lee Joo Hyun Kang Chae Seo Rhee Chul Hee Lee Tae Sup Lee Ik Joon Choi

The epidermal growth factor receptor (EGFR) is one of the most comprehensively studied molecular targets in head and neck squamous cell carcinoma (HNSCC). However, inherent and acquired resistance are serious problems and are responsible for limited clinical efficacy and tumor recurrence. In this study, we evaluated the feasibility of immuno-positron emission tomography (PET) imaging and radioi...

2015
Aurélie Derrien Sébastien Gouard Catherine Maurel Marie-Hélène Gaugler Frank Bruchertseifer Alfred Morgenstern Alain Faivre-Chauvet Jean-Marc Classe Michel Chérel

PURPOSE Ovarian peritoneal carcinomatosis is a pathology for which effective cures are currently lacking. New research protocols seek to eradicate residual micrometastases following cytoreductive surgery by using hyperthermic intraperitoneal chemotherapy (HIPEC) or radioimmunotherapy (RIT). This study aims to first develop alpha-RIT using an anti-CD138 mAb radiolabeled with an alpha-emitter, bi...

Journal: :Blood 2005
John M Bennett Mark S Kaminski John P Leonard Julie M Vose Andrew D Zelenetz Susan J Knox Sandra Horning Oliver W Press John A Radford Stewart M Kroll Robert L Capizzi

The incidence of treatment-related myelodysplastic syndromes and acute myeloid leukemia (tMDSs/tAML) after tositumomab and iodine I(131) tositumomab administration to previously treated and untreated patients with non-Hodgkin lymphoma (NHL) was evaluated. A total of 1071 patients were enrolled in 7 studies: 995 with relapsed/refractory low-grade NHL, +/- transformation (median, 3 prior regimens...

Journal: :Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2005
Shakeel Modak Nai-Kong V Cheung

Radioimmunotherapy (RIT) for pediatric tumors remains in its infancy despite its potential as an attractive therapeutic modality. Most childhood tumors are radiation sensitive, but the side effects of external beam radiation are well recognized. Despite achieving complete remissions with sophisticated combination therapies, treatment failure primarily results from the inability to eradicate min...

2015
Kentaro Fujiwara Keitaro Koyama Kosuke Suga Masako Ikemura Yasutaka Saito Akihiro Hino Hiroko Iwanari Osamu Kusano-Arai Kenichi Mitsui Hiroyuki Kasahara Masashi Fukayama Tatsuhiko Kodama Takao Hamakubo Toshimitsu Momose Salvatore V Pizzo

INTRODUCTION ROBO1 is a membrane protein that contributes to tumor metastasis and angiogenesis. We previously reported that 90Y-labeled anti-ROBO1 monoclonal antibody (90Y-anti-ROBO1 IgG) showed an antitumor effect against ROBO1-positive tumors. In this study, we performed a biodistribution study and radioimmunotherapy (RIT) against ROBO1-positive small cell lung cancer (SCLC) models. METHODS...

Journal: :Blood 2013
Johnnie J Orozco Tom Bäck Aimee Kenoyer Ethan R Balkin Donald K Hamlin D Scott Wilbur Darrell R Fisher Shani L Frayo Mark D Hylarides Damian J Green Ajay K Gopal Oliver W Press John M Pagel

Despite aggressive chemotherapy combined with hematopoietic stem cell transplantation (HSCT), many patients with acute myeloid leukemia (AML) relapse. Radioimmunotherapy (RIT) using monoclonal antibodies labeled with β-emitting radionuclides has been explored to reduce relapse. β emitters are limited by lower energies and nonspecific cytotoxicity from longer path lengths compared with α emitter...

Journal: :Blood 2003
Joseph M Tuscano Robert T O'Donnell Laird A Miers Linda A Kroger David L Kukis Kathleen R Lamborn Thomas F Tedder Gerald L DeNardo

CD22 is a membrane glycophosphoprotein found on nearly all healthy B-lymphocytes and most B-cell lymphomas. Recent in vitro studies have identified several anti-CD22 monoclonal antibodies (mAbs) that block the interaction of CD22 with its ligand. One of these mAbs, HB22.7, has been shown to effectively induce apoptosis in several B-cell lymphoma cell lines. Lymphoma xenograft studies with Raji-...

2017
Dinghu Weng Xueyan Jin Saimei Qin Xiaoli Lan Chong Chen Xun Sun Xianliang She Changling Dong Rui An

Accumulating evidence indicates that cancer stem cells (CSCs) are the cause of tumor drug/radio-resistance or distant metastasis; therefore, it is essential to eliminate CSCs to cure cancer completely. The purpose of this study was to utilize radioimmunotherapy (RIT) to target CD133(+) colonic CSCs and observe whether this prevented tumor development, by assessing the maximum tolerated dose (MT...

Journal: :Seminars in nuclear medicine 2005
Gerald L DeNardo

Most patients with non-Hodgkin's lymphoma (NHL) achieve remission but, despite newer drugs, the natural history of this disease has not improved during the last 20 years. Less than one half of patients with aggressive NHL are cured, and few of those with low-grade NHL are curable. Furthermore, NHL becomes progressively more chemoresistant while remaining responsive to external beam radiation th...

Journal: :Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2003
Krishnan Subbiah Don K Hamlin John M Pagel D Scott Wilbur Damon L Meyer Don B Axworthy Robert W Mallett Louis J Theodore Pat S Stayton Oliver W Press

UNLABELLED Pretargeted radioimmunotherapy (RIT) using streptavidin (sAv)-conjugated antibodies before radiolabeled-biotin is a promising approach to improve absorbed dose ratios and achieve high durable remission rates with diminished systemic toxicity. This study compared the immunoscintigraphy, toxicity, and therapeutic efficacy of pretargeted RIT with conventional RIT using an anti-CD20 anti...

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