AIMS The degree of systolic dysfunction does not always correlate with functional impairment in patients with congestive heart failure. In contrast, diastolic dysfunction correlates well with functional impairment. In heart failure, both elevation of N-terminal proatrial natriuretic peptide and B-type natriuretic peptide are markers of a poor prognosis. METHODS We investigated 32 patients (26...

many biological factors affect radiosensitivity. in this study, radiosensitivity among the different blood groups was investigated. peripheral blood sample of 95 healthy people were divided into two parts. one part was irradiated with 2 gy co-60 gamma rays and the second one was considered as control. then all the samples were studied by cytokinesis-blocked micronucleus assay (cbmn assay). our ...

cancer is a major cause of death worldwide and causes serious problems in human life. it is developed by uncontrolled growth of a cell or a group of cells. there are many difficulties in treatment of cancer and many researchers are involved in investigating for effective drugs to treat the disease. caryophyllaceae is a large family of about 86 genera and 2200 herbaceous or subshrub species. the...

background and objective: gastric cancer is the fourth common and the second deadliest cancer worldwide, which the major causes of its prevalence are genetic factors and the lifestyle, such as eating fast foods, physical inactivity, environmental pollution, and other natural factors. method: this research was performed in human and animal cell bank of iranian biological resource center, and cyt...

background: despite the wide range of applications, there is a serious lack of information on the impact of the nanoparticles on human health and the environment. the present study was done to determine the range of dangerous concentrations of iron oxide nanoparticle and their effects on mouse embryonic stem cells. methods: iron oxide nanoparticles with less than 20 nanometers diameter were enc...

introduction: cell culture is a process in which the cells ware isolated from original tissue, dispersed in liquid media and then placed in culture plate where the cells adhere together and propagate. today, this method is used for assessment of cell toxicity, its mechanisms and effect of different compounds on intracellular components. methods: clonogenic assay was used for assessment of cell ...

background leptospirosis is a systemic infectious disease caused by pathogenic bacteria belonging to the species of leptospira, it is considered to be the most common zoonosis in the world. this is a serious and sometimes fatal infection which is transmitted from animals to humans by entering the digestive tract or mucosal membrane. within the initial 10-12 day period, the patient may experienc...

background traditional medicines are among the oldest medicines and their extensive use in the recent years reflects the public’s interest in alternatives to conventional medicine. objectives the aim of this study was to investigate the genotoxicity of dillsun herbal medicine in dna damage of rat hepatocytes compared to sodium dichromate using a comet assay technique. materials and methods male...

improving the solubility of non-soluble herbal materials is an issue of interest in cell culture based experiments. evaluating the biological activity of these materials could become possible with the aid of cosolvents/surfactants which obviously should have little or no cytotoxic activity. in the present study, the cytotoxic activity of six cosolvents/surfactants: ethanol, methanol, tween 20 a...