The development of radiobiological models made it possible to mathematically describe biological phenomena in the body under influence radiation. history began immediately after discovery X-rays and continues now, overcoming more restrictions. practical application is an integral part clinical practice cancer treatment.

A dose and dose-rate effectiveness factor (DDREF) for low-linear energy transfer (LET) radiations (photons and electrons) is used in cancer risk assessments to represent an assumption that risks at low doses and low dose rates may be less than estimates that are based mainly on linear extrapolations of observed risks at higher acute doses. DDREF generally is assumed to be independent of energy....

AIM Radiation therapy (RT) is a standard therapeutic option for prostate cancer (PC). In the last decades, several innovative technology applications have been introduced. 3-Dimensional conformal RT, volumetric/rotational intensity modulated RT associated or not with image-guided RT, are becoming largely diffused in the treatment of PC. BACKGROUND Considering that PC could have a low α/β rati...

This study proposes a quality assurance (QA) method incorporating radiobiological factors based on the QUANTEC-determined tumor control probability and the normal tissue complication probability (NTCP) of head-and-neck intensity-modulated radiation therapy (HN-IMRT). Per-beam measurements were conducted for 20 cases using a 2D detector array. Three-dimensional predicted dose distributions withi...

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BACKGROUND There is wide interest in the use of intravascular irradiation to control restenosis following balloon angioplasty. Part of the mechanism of restenosis appears to be the proliferation of smooth muscle cells (SMCs), triggered to divide by the damage caused by the angioplasty, and this proliferation can be inhibited by irradiation with y-rays or beta-rays. METHODS In vitro data for t...

At present various sites around the world use beams of swift protons or carbon ions for radiotherapy. The success of the GSI C radiotherapy pilot project has triggered the planning and/or construction of numerous clinical ion facilities in Germany (Heidelberg, Marburg, Berlin) and Europe (CNAO, MedAustron, Etoile). These sites will use carbon ions and also protons as their prime modalities. The...

Radiobiological measurements have been made under various conditions of muliport pion irradiation using the Stanford Medical Pion Generator (SMPG). Chinese hamster cells (HA-1) were suspended in a tissue-equivalent 25% gelatin/medium solution. Hypoxic and aerobic HA-1 cells were irradiated simultaneously in a cylindrical water tank at either 4 or 16 degrees C. Irradiation at the focus of 60 con...

The physical and radiobiological experiments performed with the fast neutron beams at the cyclotron of the University of Louvain are described and discussed in view of their therapeutic applications.