OBJECT The aim of this study was to evaluate the effectiveness of brachytherapy using the GliaSite Radiation Therapy System in patients with a newly diagnosed resected single brain metastasis. The primary end point of the study was local tumor control. The secondary end points included patient survival, distant brain recurrence, quality of life, and treatment toxicity. METHODS The authors con...

PURPOSE To investigate radiation-induced carotid and cerebral vascular injury and its relationship with radiation-induced temporal lobe necrosis in nasopharyngeal carcinoma (NPC) patients. METHODS AND MATERIALS Fifty eight NPC patients with radiation-induced temporal lobe necrosis (TLN) were recruited in the study. Duplex ultrasonography was used to scan bilateral carotid arterials to evaluat...

In a consecutive series of 26 previously operated patients diagnosed with cerebral glioma, magnetic resonance spectroscopy (MRS), 2-((18)F) fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET), and perfusion MRI (MRP), were performed at follow-up to distinguish recurrence from radiation necrosis, and to identify tumour upgrading. Discrepancy between techniques was observed in 9 cases...

Aim: The purpose of this study was to compare the diagnostic accuracy of diffusion-weighted magnetic resonance imaging (DWI) and magnetic resonance spectroscopy (MRS) for the diagnosis of differentiating glioma recurrence from radiation necrosis through a meta-analysis. Methods: We performed a meta-analysis of all available studies of the diagnostic performance of DWI and MRS for differentiatin...

Purpose of the Report—The objective was to compare F-18 fluorodeoxyglucose (FDG) and F-18 fluorothymidine (FLT) positron emission tomography (PET) in differentiating radiation necrosis from recurrent glioma. Materials and methods—Visual and quantitative analyses were derived from static FDG PET and static and dynamic FLT PET in 15 patients with suspected recurrence of treated ≥ grade II glioma ...

The efficacy and toxicity of five-fraction CyberKnife radiotherapy were evaluated in patients with large brain metastases in critical areas. A total of 85 metastases in 78 patients, including tumors >30 cm(3) (4 cm in diameter) were treated with five-fraction CyberKnife radiotherapy with a median marginal dose of 31 Gy at a median prescribed isodose of 58%. Changes in the neurological manifesta...

Acute Radiation Disease (ARD) or Acute Radiation Syndromes (ARS) are defined as the collective toxic clinical states observed from the acute pathological processes in various doses of irradiated mammals; to include: systemic inflammatory response syndrome (SIRS), toxic multiple organ injury (TMOI), toxic multiple organ dysfunction syndromes (TMODS), and finally, toxic multiple organ failure (TM...

Fifty-one patients with supratentorial glioma treated with external beam radiotherapy (median dose 59.5 Gy) who then demonstrated clinical or radiographic evidence of disease progression underwent stereotactic biopsy to differentiate tumor recurrence from radiation necrosis. The original tumor histological type was diffuse or fibrillary astrocytoma in 21 patients (41%), oligodendroglioma in 13 ...

according to the direct confrontation of dentist to oral complications of patients receiving radiotherapy, this study was conducted in cancer institute of imam khomeini hospital in 1376-1377. through this study, 70 patients expecting more than 4500 cgy radiation in salivary gland area was examined for xerostomia signs and symptoms . artificial saliva and placebo were prescribed for patients to ...