Trichoderma spp. are known as a rich source of secondary metabolites with biological activity belonging to a variety of classes of chemical compounds. These fungi also are well known for their ability to produce a wide range of antibiotic substances and to parasitize other fungi. In search for new substances, which might act as anticancer agents, the overall objective of this study was to inves...

background: zinc has significant effects on structural and functional activities of many proteins and enzymes involved in biological activities, especially the regulation of immune-system. symptoms of zinc toxicity include nausea/vomiting, fever, cough, diarrhea, fatigue, neuropathy, and dehydration. further signs include growth retardation, altered iron function, anemia, copper deficiency, dec...

Breast cancer is a prevalent malignancy among women, especially in developing countries. A large number of anticancer agents with herbal origins have been reported. Hence, herbals may play an essential role in prevention and treatment of cancers. We investigated cytotoxic effects of dichloromethane fractions of Scrophularia oxysepala extract on the MCF-7 breast cancer cell line. The cytotoxic a...

1. Mesenchymal stem cell (MSC) therapy is drawing increasing attention in cardiology. However, the effect of aspirin, an assistant medication used extensively in the treatment of cardiovascular diseases, on MSC is not clear. 2. In the present study, we investigated the effect of aspirin on the growth of MSC in vitro and the underlying mechanism of its action. 3. The 3-(4,5-dimethyl-2 thiazoyl)-...

Novel bicyclo[3.3.1]nonane derivatives were synthesized by an efficient methodology from acetoacetanilide, 2-methoxy and 4-methoxyacetoacetanilides, 1,3,5-trinitrobenzene and triethylamine. The structures of the compounds were characterized by UV/Visible, FTIR, (1)H NMR and 2D-correlation spectroscopy analysis. The in vitro cytotoxic studies were performed using Ehrlich Ascites Carcinoma cell l...

The aim of this study was to investigate the apoptosis inducing property of methanolic extract of Phyllanthus polyphyllus (MPP) in vitro using human cervical cancer cells (HeLa) and human breast carcinoma cells (HBL-100). First, the anti-proliferative activity of MPP was determined using Tryphan blue dye exclusion method. Then, the apoptosis of cells was evidenced in MPP (500 μg/ml) by using pr...

Recently, regular and white mineral trioxide aggregate (MTA) are being used in Dentistry as retrofilling materials. Genotoxicity and cytotoxicity tests form an important part of cancer research and risk assessment of potential carcinogens. Thus, the goal of this study was to examine the genotoxicity and cytotoxicity of regular and white MTA in vitro by the single cell gel (comet) assay and tryp...

Trichosanthes dioica Roxb. (Cucurbitaceae), called pointed gourd in English is a dioeciously climber plant grown in India and used traditionally for various medicinal purposes. Present study evaluated antiproliferative effect of hydroalcoholic extract from T. dioica root (TDA) on Ehrlich ascites carcinoma (EAC) cells in vitro. The cytotoxic activity of TDA (1 to 10 μg/ml) against EAC cells was ...

the effects of mobile phone exposure on humans, due to its potential health hazards, have become the focus of interest since many years ago. the effect of global system for mobile communications (gsm 900 mhz) on growth and proliferation rate of mesenchymal stem cells was assessed at the different distances and intensities of radiation. a subscriber identity module (sim) card was inserted to thi...

The present study was aimed to optimize the protocol for the synthesis of silver nanoparticles using aqueous extracts of Sargassum swartzii (Turner) C.Agardh and evaluate cytotoxic potetnials using brine shrimp bio-assay activity and Trypan blue dye exclusion method. The reduction of pure Ag+ ions was monitored by measuring the UV-Vis spectrum of the solution at 200-900 nm using Shimadzu spectr...