Blood pressure exhibits substantial short- and long-term variability (BPV). We assessed the hypothesis that the complexity of beat-to-beat BPV will be differentially altered in salt-sensitive hypertensive Dahl rats (SS) versus rats protected from salt-induced hypertension (SSBN13) maintained on high-salt versus low-salt diet. Beat-to-beat systolic and diastolic BP series from nine SS and six SS...

In Pseudomonas aeruginosa, many exoproduct virulence determinants are regulated via a hierarchical quorum-sensing cascade involving the transcriptional regulators LasR and RhlR and their cognate activators, N-(3-oxododecanoyl)-L-homoserine lactone (3O-C12-HSL) and N-butanoyl-L-homoserine lactone (C4-HSL). In this paper, we demonstrate that the cytotoxic lectins PA-IL and PA-IIL are regulated vi...

Total absorption, defined as the net flux of energy out of a bounded region averaged over one cycle for time harmonic motion, must be non-negative when there are no sources of energy within the region. This passivity condition places constraints on the non-dimensional absorption coefficients of longitudinal and transverse waves, γL and γT, in isotropic linearly viscoelastic materials. Typically...

Quasi-Monte Carlo (QMC) methods are being adopted in statistical applications due to the increasingly challenging nature of numerical integrals that are now routinely encountered. For integrands with d-dimensions and derivatives of order α, an optimal QMC rule converges at a best-possible rate O(N−α/d). However, in applications the value of α can be unknown and/or a rate-optimal QMC rule can be...

The Pseudomonas aeruginosa LasR protein functions in concert with N-3-oxo-dodecanoyl-L-homoserine lactone (3O-C(12)-HSL) to coordinate the expression of target genes, including many genes that encode virulence factors, with cell density. We used a LexA-based protein interaction assay to demonstrate that LasR forms multimers only when 3O-C(12)-HSL is present. A series of LasR molecules containin...

Overdoped Tl 2Ba 2CuO 61d exhibits persistent photoconductivity at low temperatures. This effect has been observed before only in underdoped RBa 2Cu 3O 72d (R5rare earth or yttrium!. Contrary to RBa 2Cu 3O 72d , Tl 2Ba 2CuO 61d shows either a persistent increase or decrease of the carrier density with illumination, depending on doping and wavelength of the incident light. Thus it is possible to...

The reaction of C2 radical with NO molecule is studied at the B3LYP/6-311G(d) level of theory. Both doublet and quartet potential energy surfaces (PES) are considered. On the doublet potential energy surface, we obtain four major pathways in which the pathways C2 + NO h 1 CCNO f 2 (NC)CO f 3 CNCO f P1 CN + CO and C2 + NO h 1 f 4 CC(NO) f 2 f 3 f P1 CN + CO have lower energetics than the other t...

Cordia dichotoma Forst. (F. Boraginaceae) has been traditionally used for the management of a variety human ailments. In our earlier work, antidiabetic activity methanolic bark extract C. (MECD) reported. this paper, two flavonoid molecules were isolated (by column chromatography) and identified IR, NMR mass spectroscopy/spectrometry) from MECD with an aim to investigate their effectiveness. Mo...