Mycobacterium tuberculosis remains one of the world's most devastating pathogens. For this reason, we developed a study involving 3D pharmacophore searching, selectivity analysis and database screening for a series of anti-tuberculosis compounds, associated with the protein kinases A, B, and G. This theoretical study is expected to shed some light onto some molecular aspects that could contribu...

BACKGROUND The current study investigated the analgesic effect of the Toll-like receptor 4 (TLR4) specific antagonist TAK-242 on neuropathic pain in rats and its underlying mechanism. METHODS A total of 132 adult Sprague-Dawley (SD) rats were randomly divided into four groups: the sham operation group, the neuropathic pain model group, the TAK-242 low-dose treatment group, and the TAK-242 hig...

In Sweeney v Boylan Nominees Pty Ltd the High Court affirmed that a principal is not vicariously liable for the negligent acts of an independent contractor. In this case a mechanic engaged by Boylan negligently performed repair work, resulting in an injury to Mrs Sweeney. Since the mechanic was a contractor rather than an employee, Mrs Sweeney was unsuccessful in her action against Boylan. Whil...

Turbine Engine Diagnostics (TED) is a diagnostic expert system to aid the Ml Abrams tank mechanic find and fix problems in the AGT-1500 turbine engine. TED was designed to provide the apprentice mechanic the’ability to diagnose and repair the turbine engine like an expert mechanic. The expert system was designed and built by the U.S. Army Research Laboratory ,I_. \ ~HKLJ and the U.S. Army Ordna...