Genetic association studies determine how genes influence traits. However, non-detected population substructure may bias the analysis, resulting in spurious results. One method to detect substructure is to genotype ancestry informative markers (AIMs) besides the candidate variants, quantifying how much ancestral populations contribute to the samples' genetic background. The present study aimed ...

genetic diversity is the basis success of improving the quality and quantity of crops. recognizing of genetic diversity and genetic potential of each plant species in plant breeding is necessary. in this study genetic diversity of 30 lentil samples belonging to collection of the college of agriculture of krage were evaluated using rapd molecular markers. rapd products were scored for presence (...

Inference of individual ancestry is useful in various applications, such as admixture mapping and structured-association mapping. Using information-theoretic principles, we introduce a general measure, the informativeness for assignment (I(n)), applicable to any number of potential source populations, for determining the amount of information that multiallelic markers provide about individual a...

The recent revolution in science and technology applied to medical research has left in its wake a trial of biomedical data and human samples; however, its opportunities remain largely unfulfilled due to a number of legal, ethical, financial, strategic, and technical barriers. Precision oncology has been at the vanguard to leverage this potential of "Big data" and samples into meaningful soluti...

Testing for deviations from Hardy-Weinberg equilibrium is a widely recommended practice for population-based genetic association studies. However, current methods for this test assume a simple random sample and may not be appropriate for sample surveys with complex survey designs. In this paper, the authors present a test for Hardy-Weinberg equilibrium that adjusts for the sample weights and co...

We investigated discrimination of large quantities in salamanders of the genus Plethodon. Animals were challenged with two different quantities (8 vs 12 or 8 vs 16) in a two-alternative choice task. Stimuli were live crickets, videos of live crickets or images animated by a computer program. Salamanders reliably chose the larger of two quantities when the ratio between the sets was 1:2 and stim...

We live in the era of rankings. Universities are being ranked, journals are being ranked, and researchers are being ranked. In this era of rankings, the value of researchers is measured in the number of their papers published, the citations they received, and the volume of grant income earned. Academia today is governed by one simple rule: more is better. The idea to reward those who are produc...

This paper reports the syntactic distribution of amwu-N-to/-irato/-ina phrases, which are representative polarity sensitive items (PSIs) in Korean, and accounts for their semantic characteristics in terms of "arbitrary choice quantification" and "concession." In the first section, we extensively illustrate the distributional behaviour of the PSIs in various constructions and roughly generalizes...

Embryonic stem cell-derived mesenchymal stromal cells (MSCs; also known as mesenchymal stem cells) represent a promising source for bone regenerative medicine. Despite remarkable advances in stem cell biology, the molecular mechanism regulating differentiation of human embryonic stem cells (hESCs) into MSCs remains poorly understood. Here, we report that inhibition of IκB kinase (IKK)/nuclear f...