نتایج جستجو برای: pyruvate kinase

تعداد نتایج: 238659  

2009
BHANU ODEDRA DENNIS P. BRILEY NORMAN PALMER

Hitherto it has been generally supposed that pyruvate kinase (EC 2.7.1.40) has no significant role in the regulation in vivo of glycolytic flux in skeletal muscle (Carbonell et al., 1973). This supposition, apart from providing an explanation for the apparent lack of potentially regulatory allosteric interactions by skeletal-muscle (M-type) pyruvate kinase, is in agreement with the idea that gl...

Journal: :Haematologica 2008
Edmir Boturão-Neto Akemi K Chiba Perla Vicari Maria S Figueiredo José O Bordin

1. Zanella A, Fermo E, Bianchi P, Chiarelli LR, Valentini G. Pyruvate kinase deficiency: The genotype-phenotype association. Blood Rev 2007;12:12. 2. Van Wijk R, Van Solinge WW, Nerlov C, Beutler E, Gelbart T, Rijksen G, et al. Disruption of a novel regulatory element in the erythroid-specific promoter of the human PKLR gene causes severe pyruvate kinase deficiency. Blood 2003;101:1596-602. 3. ...

Journal: :The Journal of biological chemistry 1984
A Weber J Marie D Cottreau M P Simon C Besmond J C Dreyfus A Kahn

Liver L-type pyruvate kinase and aldolase B mRNAs are the two species whose translational activity increases the most after feeding starved rats a high carbohydrate diet (Simon, M. P., Besmond, C., Cottreau, D., Weber, A., Chaumet-Riffaud, P., Dreyfus, J. C., Sala Trépat, J., Marie, J., and Kahn, A. (1984) J. Biol. Chem., in press). We therefore compared the pattern of this induction in three t...

2009

-. 1 3 . Miernyk. J. A. & Dennis. I>. 1 ( 1982) I’lurit I’hyxiol. 69. 825-828 Journet. E. P. & Douce. R. ( 1 984) (‘. K. Acud. Sci. /’(iris Ser. 111 298, 365-370 Hotha, F. C. & Dennis, D. R. ( 1986) Arch. Bioc,hem. Bioplrvs. 245.96I03 Fothergill. L. A. & Harkins. R. N . ( 1982) /’roc.. K. Soc. London H215, 19-44 White. M. F. & Fothergill-Gilmore. L. A. (1988) FEES Lett. 229,383-387 Winn. S. I.,...

Journal: :The Journal of biological chemistry 1977
R Rognstad J Katz

Glucagon and L-epinephrine stimulate gluconeogenesis from 20 mM L-lactate, the effect being about 3 times greater in liver cells from fed rats than in those from fasted rats. The rate of pyruvate kinase flux was estimated to be less than 10% of the rate of gluconeogenesis from lactate in hepatocytes from fasted rats, and neither glucagon nor epinephrine lowered the absolute rate significantly. ...

Journal: :Biochimica et biophysica acta 1959
E A DAVIDSON

Short Communications Specificity of pyruvate kinase Previous reports have indicated that pyruvate kinase is a relatively non-specific enzyme capable of catalyzing the transfer of phosphate from PEP to a wide variety of nucleoside diphosphate acceptors l& In the present studies, attempts were made to utilize this enzyme for the assay of UDP.The rate of phosphate transfer to nucleoside diphosphat...

Journal: :Biochimie 1981
H A Buc F Demaugre A Moncion J P Leroux

The effects of oxalate on glycolysis and glucose production from trioses were studied in hepatocytes isolated from fed and fasted rats. 1--In cells from fed rats oxalate inhibited glycolysis at the pyruvate kinase step, as shown by an increased phosphoenolpyruvate concentration, a decreased lactate and pyruvate production and a reduction of the glycolytic flux estimated by the rate of detritiat...

Journal: :Applied and environmental microbiology 2017
Chunhua Zhao Zhao Lin Hongjun Dong Yanping Zhang Yin Li

Pyruvate kinase is one of the three rate-limiting glycolytic enzymes that catalyze the last step of glycolysis, conversion of phosphoenolpyruvate (PEP) into pyruvate, which is associated with ATP generation. Two isozymes of pyruvate kinase, PykF and PykA, are identified in Escherichia coli PykF is considered important, whereas PykA has a less-defined role. Prior studies inactivated the pykA gen...

2013
Clair Crewe Michael Kinter Luke I. Szweda

Cardiac function depends on the ability to switch between fatty acid and glucose oxidation for energy production in response to changes in substrate availability and energetic stress. In obese and diabetic individuals, increased reliance on fatty acids and reduced metabolic flexibility are thought to contribute to the development of cardiovascular disease. Mechanisms by which cardiac mitochondr...

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