Isoniazid is the mainstay of antitubercular therapy and is included in nearly every drug regime. Cases of intentional and accidental overdose have been reported(l,2) though with less than expected frequency considering the drug's extensive use. The principal manifestations of isoniazid overdose include recurrent seizures, metabolic acidosis and coma(3,4). We report two cases of isoniazid overdo...

Pyridoxine hydrochloride is water-soluble B vitamin widely used for the prevention and treatment of vitamin B6 deficiency and other several diseases. The aim of this study was to explore the effect of The Trivedi Effect Energy of Consciousness Healing Treatment on the physicochemical and thermal properties of pyridoxine hydrochloride using PXRD, PSA, DSC, and TGA/DTG analysis. Pyridoxine hydroc...

A review of the adverse effects of isoniazid (INH) wm undertaken and it was found that these effects could be divided into: (1) toxic, (2) idiosyncratic and (3) hypersensitivity reactions. Major toxic reactions are peripheral neuropathies at conventional dosage and seizures from overdosage. Pyridoxine is of benefit in these disorders. Other presumed toxic reactions are autonomic neuropathy, enc...

Although ginkgo is commonly used as an alternative treatment for memory loss, Alzheimer's dementia and peripheral circulatory disturbances, it is also known to cause neuronal symptoms due to ginkgotoxin (4'-methoxypyridoxine or B6 antivitamin). We experienced a case of a 51-year-old female patient with generalized tonic clonic seizure and postictal confusion after eating large amounts of ginkgo...

BACKGROUND Pyridoxine-dependent seizures (PDS) is a rare, autosomal recessively inherited disorder. Recently alpha-aminoadipic semialdehyde (alpha-AASA) dehydrogenase deficiency was identified as a major cause of PDS, which causes accumulation of both alpha-AASA and pipecolic acid (PA) in body fluids. METHODS We studied urinary and plasma alpha-AASA and PA levels in 12 Dutch clinically diagno...

Seizures may be the first and the major presenting feature of an inborn error of metabolism (IEM), for example in a neonate with pyridoxine-dependent epilepsy. In other IEMs, seizures may be preceded by other major symptoms: by a reduced level of consciousness in a child with an organic acidaemia or urea cycle defect; or by loss of skills, progressive weakness, ataxia, and upper motor signs in ...

Introduction Pyridoxine-dependent epilepsy (PDE) is a rare autosomal recessive disease usually associated with neonatal seizures that are sensitive to pyridoxine (vitamin B6). This can have significant impact on family functioning, psychological distress in parents. Post-traumatic stress disorder (PTSD), depression, and anxiety the most common psychiatric outcomes parents of children PDE. Objec...